Adverse childhood experiences (ACEs), such as maltreatment and severe household
dysfunction, represent a significant threat to public health as ACEs are associated with …

Childhood adversity, such as neglect, or physical, emotional, or sexual abuse, is prevalent in
the US and worldwide, and connected to an elevated incidence of disease in adulthood. A …

Childhood adversity is associated with increased risk for onset of depressive episodes. This
review will present evidence that allostatic overload of the hypothalamic–pituitary–adrenal …

Objective Dysregulation of autonomic nervous system and hypothalamic-pituitary-adrenal
(HPA) axis function is a putative intermediate phenotype linking childhood adversity (CA) …

Background and objectives: After a previous report demonstrated blunted heart rate (HR)
reactivity in association with adverse childhood experiences (ACEs)[Voellmin, A., Winzeler …

Childhood adversity has been repeatedly and robustly linked to physical and mental illness
across the lifespan. Yet, the biological pathways through which this occurs remain unclear …

Background Chronic or prolonged stress exposure in childhood can alter structural and
functional brain development, leading to mental and physical illness and alterations of …

How do adverse childhood experiences get 'under the skin'and influence health outcomes
through the life-course? Research reviewed here suggests that adverse childhood …

There is a relative consensus about the detrimental impact of childhood maltreatment on
later mental health problems and behavioral difficulties. Prior research suggests that …

Adverse childhood experiences (ACEs) are associated with poor future mental and physical
health. Altered biological reactivity to mental stress may be a possible mechanism linking …