Platinum compounds represent one of the great success stories of metals in medicine.
Following the unexpected discovery of the anticancer activity of cisplatin (Fig. 1) in 1965 by …

Platinum compounds are of paramount importance in the treatment of malignancies and are
being widely used worldwide in clinical practice [1]. The efforts to unveil their mechanisms of …

In the years since the discovery of cisplatin, the search for new platinum-based antitumor
agents has grown at a staggering rate. Several thousand platinum complexes have been …

Cisplatin, carboplatin and oxaliplatin are highly effective metal-based anticancer agents
used in 50% of all tumor therapies all over the world. Besides the fact that these compounds …

In the next two decades, the world is expected to see around 20 million cases of cancer.
Moreover, the types of cancer will vary considerably from country to other. Therefore, all …

Commercial sources of platinum are sulfide and arsenide minerals and, increasingly,
recycled platinum. The main source of platinum in the environment is release from vehicle …

The discovery of the anticancer properties of platinum derivatives by Rosenberg [1–3]
represents a milestone in the development of chemotherapeutic protocols for tumor …

The limitations of cisplatin as an anticancer drug have stimulated the search for other
antitumour-active platinum complexes with improved pharmacological properties. The two …

It is over twenty years since cisplatin was first given to cancer patients, and a decade since
the initiation of clinical trials of carboplatin. Nevertheless, platinum-based cancer therapy …

The limitations of cisplatin as an anticancer drug have stimulated the search for other
antitumor-active platinum complexes with improved pharmacological properties. The two …