Persistently high serum substance P levels and early mortality in patients with severe traumatic brain injury

L Lorente, MM Martín, A Pérez-Cejas… - World neurosurgery, 2019 - Elsevier
Background Substance P is a neuropeptide belonging to the tachykinin family and is
involved in neuroinflammation. In a previous study by our team, we found higher serum …

High serum substance P levels and mortality after malignant middle cerebral artery infarction

L Lorente, MM Martín, A Pérez-Cejas… - Journal of Critical …, 2020 - Elsevier
Purpose Previously our team found higher serum substance P concentrations at day 1 of a
malignant middle cerebral artery infarction (MMCAI) in non-surviving than in surviving …

Serum substance P levels and early mortality of spontaneous intracerebral haemorrhage patients

L Lorente, MM Martín, AF González-Rivero… - Journal of Stroke and …, 2020 - Elsevier
Introduction and goal Substance P, a neuropeptide of the tachykinin family, is involved in the
neuroinflammation of different diseases of the central nervous system. To our knowledge …

Serum substance P concentration in children with traumatic brain injury: A First Report

Y Zhou, H Ye, W Lu - World Neurosurgery, 2021 - Elsevier
Objective To review the clinic value and severity assessment of serum substance P (SP)
concentration in children with different degrees of traumatic brain injury (TBI) through …

[HTML][HTML] Serum levels of substance P and mortality in patients with a severe acute ischemic stroke

L Lorente, MM Martín, T Almeida… - International Journal of …, 2016 - mdpi.com
Substance P (SP), a member of tachykinin family, is involved in the inflammation of the
central nervous system and in the appearance of cerebral edema. Higher serum levels of SP …

A multi-staged neuropeptide response to traumatic brain injury

JL Alves, J Mendes, R Leitão, AP Silva… - European Journal of …, 2020 - Springer
Purpose As the most abundant neuropeptides in Central Nervous System, Substance P and
Neuropeptide Y are arguably involved in the response to brain trauma. This study aims to …

[HTML][HTML] Serum substance P levels are associated with severity and mortality in patients with severe traumatic brain injury

L Lorente, MM Martín, T Almeida, M Hernández… - Critical care, 2015 - Springer
Abstract Introduction Substance P (SP) is a member of the tachykinin family of
neuropeptides, which are widely distributed throughout the central nervous system (CNS) …

[图书][B] Substance P immunoreactivity increases following human traumatic brain injury

AC Zacest, R Vink, J Manavis, GT Sarvestani… - 2010 - Springer
Recent experimental evidence suggests that neuropeptides, and in particular substance P
(SP), are released following traumatic brain injury (TBI) and may play a significant role in the …

The role of substance P within traumatic brain injury and implications for therapy

A Safwat, A Helmy, A Gupta - Journal of Neurotrauma, 2023 - liebertpub.com
This review examines the role of the neuropeptide substance P within the
neuroinflammation that follows traumatic brain injury. It examines it in reference to its …

Potential role of serum substance P as a favorable biomarker of functional outcome in acute spontaneous intracerebral hemorrhage

G Wang, CJ He, XS Liang, YF Zhou, SH Chen - Clinica Chimica Acta, 2020 - Elsevier
Abstract Background Substance P (SP) is implicated in brain inflammation. We clarified
relationship between serum SP concentrations and functional outcome of acute …