In 2014, we proposed that orexin signaling transformed motivationally relevant states into
adaptive behavior directed toward exploiting an opportunity or managing a threat, a process …

Although originally implicated in appetite and sleep/wakefulness, the hypothalamic orexin
(hypocretin) system has now been demonstrably linked with motivated behavior. This highly …

Orexins/hypocretins are hypothalamic peptides involved in arousal and wakefulness, but
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …

The orexins (or hypocretins) are hypothalamic neuropeptides that have been implicated in a
variety of behaviors ranging from feeding to sleep and arousal. Evidence from animal …

Orexins (also known as hypocretins) are neuropeptides that participate in the regulation of
energy metabolism, homeostasis, sleep, feeding, stress responses, arousal, and reward …

One decade ago, our laboratory provided the first direct evidence linking orexin/hypocretin
signaling with drug seeking by showing that activation of these neurons promotes …

The orexins (or hypocretins) are hypothalamic neuropeptides involved in the regulation of a
variety of complex behaviors, ranging from feeding to sleep and arousal (Adamantidis and …

Background The orexin (hypocretin) system is important for reward-driven motivation but has
not been implicated in the expression of a multiphenotype addicted state. Methods Rats …

Addiction is a devastating disorder that affects 15.3 million people worldwide. While
prevalent, few effective treatments exist. Orexin receptors have been proposed as a potential …

Hypocretins (also known as orexins) are hypothalamic neuropeptides involved in the
regulation of sleep/wake states and feeding behavior. Recent studies have also …