Introduction Multi-drug resistance (MDR) is a hindrance toward the successful treatment of
cancers. The primary mechanism that gives rise to acquired chemoresistance is the …

The adenosine triphosphate binding cassette (ABC) transporters are one of the largest
transmembrane gene families in humans. The ABC transporters are present in a number of …

Introduction: Most disseminated cancers remain fatal despite the availability of a variety of
conventional and novel treatments including surgery, chemotherapy, radiotherapy …

Adenine triphosphate (ATP)-binding cassette (ABC) transporter proteins, such as ABCB1/P-
glycoprotein (P-gp) and ABCG2/breast cancer resistance protein (BCRP), transport various …

For most cancers, the treatment of choice is still chemotherapy despite its severe adverse
effects, systemic toxicity and limited efficacy due to the development of multidrug resistance …

Multidrug resistance (MDR) is a major obstacle to successful cancer treatment. It is often
associated with an increased efflux of a variety of structurally unrelated anticancer drugs by …

ATP-Binding Cassette (ABC) transporters are important mediators of multidrug resistance
(MDR) in patients with cancer. Although their role in MDR has been extensively studied in …

A variety of human cancers become resistant or are intrinsically resistant to treatment with
conventional chemotherapy, a phenomenon called multidrug resistance. This broad-based …

Cancer cells frequently display intrinsic or acquired resistance to chemically diverse
anticancer drugs, limiting therapeutic success. Among the main mechanisms of this …

The ATP binding-cassette superfamily corresponds the mostly transmembrane transporters
family found in humans. These proteins actively transport endogenous and exogenous …