Different mechanisms of drug resistance, including ATP-binding cassette (ABC) transporters,
are responsible for treatment failure of tumors. We developed a low-density DNA microarray …

Breast cancer resistance protein (BCRP/ABCG2) is a novel member of ATP-binding cassette
transporters, which induce multidrug resistance in cancer cells. We found that a high level of …

Overexpression of ATP-binding cassette (ABC) transporters is a cause of drug resistance in
a plethora of tumors. More recent evidence indicates additional contribution of these …

Drug metabolism is an orchestrated process in which drugs are metabolized and disposed
through a series of specialized enzymes and transporters. Alterations in the expression …

Recent studies have shown that a number of microRNAs (miRNA or miR) may regulate
human breast cancer resistance protein (BCRP/ABCG2), an important efflux transporter …

Multidrug resistance (MDR) is one of the main impediments in the treatment of cancers.
MDR cancer cells are resistant to multiple anticancer drugs. One of the major mechanisms of …

The development of drug resistance continues to be a dominant hindrance toward curative
cancer treatment. Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and …

Resistance to chemotherapy is a common clinical problem in patients with infectious
diseases as well as in patients with cancer. During treatment of infections or malignant …

Multidrug resistance (MDR) is the phenomenon in which cancer cells simultaneously
develop resistance to a broad spectrum of structurally and mechanistically unrelated drugs …

The multidrug resistance (MDR) phenomenon in cancer cells is the major obstacle leading
to failure of chemotherapy accompanied by the feature of intractable and recurrence of …