Highlights•The most common reason for the failure of the cancer treatment is the evolving
drug resistance.•The ABC transporters mainly P-gp, BCRP and MRP1 are responsible for …

Resistance to chemotherapy is a common clinical problem in patients with infectious
diseases as well as in patients with cancer. During treatment of infections or malignant …

ATP-binding cassette (ABC) transporters are known to play an important role in human
physiology, toxicology, pharmacology, and numerous disorders including acute myeloid …

Multidrug resistance caused by the overexpression of ABC drug transporters is a major
obstacle in clinical cancer chemotherapy. For several years, it appeared that direct inhibition …

The multidrug resistance (MDR) phenotype exhibited by cancer cells is believed to be the
major barriers to successful chemotherapy in cancer patients. The major form of MDR …

The risk of acquisition of resistance to chemotherapy remains a major hurdle in the
management of various types of cancer patients. Several cellular and noncellular …

Multidrug resistance is a key determinant of cancer chemotherapy failure. One of the major
causes of multidrug resistance is the enhanced efflux of drugs by membrane ABC …

Worldwide, colorectal cancer (CRC) is the third most common cancer, with the highest
mortality rates occurring in Central Europe. The use of chemotherapy to treat CRC is limited …

Reduced drug accumulation due to overexpression of individual members of the ATP
binding cassette (ABC) superfamily of membrane transporters has been investigated as a …

The human breast cancer resistance protein (BCRP, gene symbol ABCG2) is an ATP-
binding cassette (ABC) efflux transporter. It was so named because it was initially cloned …