Multiple drug resistance (MDR), referring to the resistance of cancer cells to a broad
spectrum of structurally and mechanistically unrelated drugs across membranes, severely …

ABCG2, or breast cancer resistance protein (BCRP), is an ABC transporter that has been the
subject of intense study since its discovery a decade ago. With high normal tissue …

Abstract Development of taxane resistance has become clinically very important issue. The
molecular mechanisms underlying the resistance are still unclear. To address this issue, we …

The breast cancer resistance protein, BCRP/ABCG2, is a half-molecule ATP-binding
cassette transporter that facilitates the efflux of various anticancer agents from the cell …

Abstract ABCG2/MXR/ABCP1/BCRP is a member of the ATP‐binding cassette membrane
transporter, which consists of six transmembrane regions and one ATP‐binding cassette …

Adenosine triphosphate (ATP)‐binding cassette (ABC) transporters are drug efflux pumps
responsible for the multidrug resistance phenotype causing hepatocellular carcinoma (HCC) …

Chemoresistance including intrinsic and acquired anticancer drug resistance continues to
be a primary hindrance towards curative cancer treatment. Therefore, deciphering the …

Multidrug resistance (MDR) of cancer is a persistent problem in chemotherapy. Scientists
have considered the overexpressed efflux transporters responsible for MDR and …

Background Statistics on cancer incidence and mortalities indicate that this disease still has
a fatal outcome for a majority of patients due to non-sufficient treatment. The options …

Non-coding RNAs (ncRNAs) have been implicated in most cellular functions. The disruption
of their function through somatic mutations, genomic imprinting, transcriptional and post …