Stress can affect reproductive performance of lactating cows by targeting the ovarian pool of
follicles and their enclosed oocytes. Among the documented stressors are heat stress (ie …

Mitochondria transfer techniques were first designed to prevent the transmission of diseases
due to mutations in mtDNA, as these organelles are exclusively transmitted to the offspring …

Insulin resistance is a key defect associated with obesity, type 2 diabetes and other
metabolic diseases. While a number of factors have been suggested to cause defects in …

The negative impact of obesity on reproductive success is well documented but the stages at
which development of the conceptus is compromised and the mechanisms responsible for …

Mitochondria are the most abundant organelles in the mammalian oocyte and early embryo.
While their role in ATP production has long been known, only recently has their contribution …

Mitochondria play a primary role in cellular energetic metabolism, homeostasis, and death.
They possess their own multicopy genome, which is maternally transmitted. Mitochondria …

Reduced quality in oocytes from women of advanced maternal age (AMA) is associated with
dysfunctional mitochondria. The objective of this study was to investigate the mechanisms …

Mitochondria are responsible for the production of ATP, which drives cellular metabolic and
biosynthetic processes. This is the first study to quantify the mtDNA copy number across all …

The decline of oocyte quality has profound impacts on fertilization, implantation, embryonic
development, and the genetic quality of future generations. One factor that is often ignored …

The present study was designed to determine whether controlled ovarian hyperstimulation
(COH) and in vitro maturation (IVM), two common clinical procedures in human IVF …