miR-31: a key player in CD8 T-cell exhaustion
Over the past decade, miRNAs have emerged as genetic factors that can influence immune
functions. 1 They act by post-transcriptionally downregulating gene expression either by …
functions. 1 They act by post-transcriptionally downregulating gene expression either by …
The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection
During infection, antigen-specific T cells undergo tightly regulated developmental transitions
controlled by transcriptional and post-transcriptional regulation of gene expression. We …
controlled by transcriptional and post-transcriptional regulation of gene expression. We …
[HTML][HTML] MicroRNA high throughput loss-of-function screening reveals an oncogenic role for miR-21-5p in Hodgkin lymphoma
Y Yuan, F Niu, IM Nolte, J Koerts, D De Jong… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Classical Hodgkin lymphoma (cHL) is among the most frequent
lymphoma subtypes. The tumor cells originate from crippled germinal center (GC)-B cells …
lymphoma subtypes. The tumor cells originate from crippled germinal center (GC)-B cells …
MicroRNA regulatory networks and human disease
YY Mo - Cellular and molecular life sciences, 2012 - Springer
MicroRNAs are a class of naturally occurring small noncoding RNAs that control gene
expression by a posttranscriptional repression mechanism [1–3]. Since their discovery [4–6] …
expression by a posttranscriptional repression mechanism [1–3]. Since their discovery [4–6] …
Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation
MicroRNAs are important regulators of various developmental and physiological processes.
However, their roles in the CD8+ T-cell response are not well understood. Using an acute …
However, their roles in the CD8+ T-cell response are not well understood. Using an acute …
Micro-RNA 155 is required for optimal CD8+ T cell responses to acute viral and intracellular bacterial challenges
Recent studies have begun to define the role of micro-RNAs in regulating the immune
response. Micro-RNA155 (mir-155) has been shown to play a role in germinal center …
response. Micro-RNA155 (mir-155) has been shown to play a role in germinal center …
MiR-33a suppresses proliferation of NSCLC cells via targeting METTL3 mRNA
M Du, Y Zhang, Y Mao, J Mou, J Zhao, QI Xue… - Biochemical and …, 2017 - Elsevier
Abstract Methyltransferase like 3 (METTL3) was incipiently known as a methyltransferase
which was responsible for N 6-methyladenosine (m 6 A) methylation. METTL3 can promote …
which was responsible for N 6-methyladenosine (m 6 A) methylation. METTL3 can promote …
The emerging role of miRNA-122 in infectious diseases: Mechanisms and potential biomarkers
R Mirzaei, S Karampoor, NL Korotkova - Pathology-Research and Practice, 2023 - Elsevier
Abstract microRNAs (miRNAs) are small, non-coding RNA molecules that play crucial
regulatory roles in numerous cellular processes. Recent investigations have highlighted the …
regulatory roles in numerous cellular processes. Recent investigations have highlighted the …
MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis
G Murugaiyan, AP Da Cunha, AK Ajay… - The Journal of …, 2015 - Am Soc Clin Investig
Accumulation of IL-17–producing Th17 cells is associated with the development of multiple
autoimmune diseases; however, the contribution of microRNA (miRNA) pathways to the …
autoimmune diseases; however, the contribution of microRNA (miRNA) pathways to the …
Restoration of microRNA-212 causes a G0/G1 cell cycle arrest and apoptosis in adult T-cell leukemia/lymphoma cells by repressing CCND3 expression
H Wang, Q Guo, P Yang… - Journal of Investigative …, 2017 - journals.sagepub.com
Adult T-cell leukemia/lymphoma (ATL) is a highly aggressive T-cell malignancy. This study
was designed to explore the expression and functional significance of microRNA (miR)-212 …
was designed to explore the expression and functional significance of microRNA (miR)-212 …