[HTML][HTML] A Conserved Gcn2-Gcn4 Axis Links Methionine Utilization and the Oxidative Stress Response in Cryptococcus neoformans
AK Stovall, CM Knowles, MC Kalem… - Frontiers in fungal …, 2021 - frontiersin.org
The fungal pathogen Cryptococcus neoformans relies on post-transcriptional mechanisms of
gene regulation to adapt to stressors it encounters in the human host, such as oxidative …
gene regulation to adapt to stressors it encounters in the human host, such as oxidative …
Mitochondrial Morphology, Oxidative Stress Resistance, and Pathogenesis in Cryptococcus neoformans
AL Chang - 2020 - openscholarship.wustl.edu
Cryptococcus neoformans is an important pathogen that annually kills 200,000 people
worldwide. It survives in the environment as a yeast or spore and can also proliferate within …
worldwide. It survives in the environment as a yeast or spore and can also proliferate within …
Cdk8 and Ssn801 Regulate oxidative stress resistance and virulence in Cryptococcus neoformans
AL Chang, Y Kang, TL Doering - MBio, 2019 - Am Soc Microbiol
Cryptococcus neoformans kills 200,000 people worldwide each year. After inhalation, this
environmental yeast proliferates either extracellularly or within host macrophages. Under …
environmental yeast proliferates either extracellularly or within host macrophages. Under …
Uncoupling of mRNA synthesis and degradation impairs adaptation to host temperature in Cryptococcus neoformans
ALM Bloom, JTG Solomons, VE Havel… - Molecular …, 2013 - Wiley Online Library
The pathogenic fungus C ryptococcus neoformans must overcome multiple stressors to
cause disease in its human host. In this study, we report that C. neoformans rapidly and …
cause disease in its human host. In this study, we report that C. neoformans rapidly and …
CNBP homologues Gis2 and Znf9 interact with a putative G-quadruplex-forming 3′ untranslated region, altering polysome association and stress tolerance in …
J Leipheimer, ALM Bloom, T Baumstark, JC Panepinto - Msphere, 2018 - Am Soc Microbiol
In Cryptococcus neoformans, mRNAs encoding ribosomal proteins (RP) are rapidly and
specifically repressed during cellular stress, and the bulk of this repression is mediated by …
specifically repressed during cellular stress, and the bulk of this repression is mediated by …
Landscape of gene expression variation of natural isolates of Cryptococcus neoformans in response to biologically relevant stresses
Cryptococcus neoformans is an opportunistic fungal pathogen that at its peak epidemic
levels caused an estimated million cases of cryptococcal meningitis per year worldwide …
levels caused an estimated million cases of cryptococcal meningitis per year worldwide …
Opposing PKA and Hog1 signals control the post‐transcriptional response to glucose availability in Cryptococcus neoformans
D Banerjee, ALM Bloom… - Molecular …, 2016 - Wiley Online Library
The pathogenic fungus Cryptococcus neoformans must adapt to glucose‐limited conditions
in the lung and glucose replete conditions upon dissemination to the brain. We report that …
in the lung and glucose replete conditions upon dissemination to the brain. We report that …
Cellular Coordinators: Mechanisms by Which Non-Enzymatic Proteins Contribute to Growth and Cell Surface Remodeling in the Human Fungal Pathogen …
CL Telzrow - 2022 - search.proquest.com
My thesis work has focused on characterizing mechanisms by which human fungal
pathogens regulate their adaptive cellular responses in order to survive and cause disease …
pathogens regulate their adaptive cellular responses in order to survive and cause disease …
Glucan unmasking identifies regulators of temperature-induced translatome reprogramming in C. neoformans
ALM Bloom, D Goich, CM Knowles, JC Panepinto - Msphere, 2021 - Am Soc Microbiol
The cell walls of fungi are critical for cellular structure and rigidity but also serve as a major
communicator to alert the cell to the changing environment. In response to stresses …
communicator to alert the cell to the changing environment. In response to stresses …
[HTML][HTML] Ionizing radiation and chemical oxidant exposure impacts on Cryptococcus neoformans transfer RNAs
M Kelley, MJ Paulines, G Yoshida, R Myers, M Jora… - PloS one, 2022 - journals.plos.org
Cryptococcus neoformans is a fungus that is able to survive abnormally high levels of
ionizing radiation (IR). The radiolysis of water by IR generates reactive oxygen species …
ionizing radiation (IR). The radiolysis of water by IR generates reactive oxygen species …