[HTML][HTML] A Conserved Gcn2-Gcn4 Axis Links Methionine Utilization and the Oxidative Stress Response in Cryptococcus neoformans

AK Stovall, CM Knowles, MC Kalem… - Frontiers in fungal …, 2021 - frontiersin.org
The fungal pathogen Cryptococcus neoformans relies on post-transcriptional mechanisms of
gene regulation to adapt to stressors it encounters in the human host, such as oxidative …

Mitochondrial Morphology, Oxidative Stress Resistance, and Pathogenesis in Cryptococcus neoformans

AL Chang - 2020 - openscholarship.wustl.edu
Cryptococcus neoformans is an important pathogen that annually kills 200,000 people
worldwide. It survives in the environment as a yeast or spore and can also proliferate within …

Cdk8 and Ssn801 Regulate oxidative stress resistance and virulence in Cryptococcus neoformans

AL Chang, Y Kang, TL Doering - MBio, 2019 - Am Soc Microbiol
Cryptococcus neoformans kills 200,000 people worldwide each year. After inhalation, this
environmental yeast proliferates either extracellularly or within host macrophages. Under …

Uncoupling of mRNA synthesis and degradation impairs adaptation to host temperature in Cryptococcus neoformans

ALM Bloom, JTG Solomons, VE Havel… - Molecular …, 2013 - Wiley Online Library
The pathogenic fungus C ryptococcus neoformans must overcome multiple stressors to
cause disease in its human host. In this study, we report that C. neoformans rapidly and …

CNBP homologues Gis2 and Znf9 interact with a putative G-quadruplex-forming 3′ untranslated region, altering polysome association and stress tolerance in …

J Leipheimer, ALM Bloom, T Baumstark, JC Panepinto - Msphere, 2018 - Am Soc Microbiol
In Cryptococcus neoformans, mRNAs encoding ribosomal proteins (RP) are rapidly and
specifically repressed during cellular stress, and the bulk of this repression is mediated by …

Landscape of gene expression variation of natural isolates of Cryptococcus neoformans in response to biologically relevant stresses

CH Yu, Y Chen, CA Desjardins, JL Tenor… - Microbial …, 2020 - microbiologyresearch.org
Cryptococcus neoformans is an opportunistic fungal pathogen that at its peak epidemic
levels caused an estimated million cases of cryptococcal meningitis per year worldwide …

Opposing PKA and Hog1 signals control the post‐transcriptional response to glucose availability in Cryptococcus neoformans

D Banerjee, ALM Bloom… - Molecular …, 2016 - Wiley Online Library
The pathogenic fungus Cryptococcus neoformans must adapt to glucose‐limited conditions
in the lung and glucose replete conditions upon dissemination to the brain. We report that …

Cellular Coordinators: Mechanisms by Which Non-Enzymatic Proteins Contribute to Growth and Cell Surface Remodeling in the Human Fungal Pathogen …

CL Telzrow - 2022 - search.proquest.com
My thesis work has focused on characterizing mechanisms by which human fungal
pathogens regulate their adaptive cellular responses in order to survive and cause disease …

Glucan unmasking identifies regulators of temperature-induced translatome reprogramming in C. neoformans

ALM Bloom, D Goich, CM Knowles, JC Panepinto - Msphere, 2021 - Am Soc Microbiol
The cell walls of fungi are critical for cellular structure and rigidity but also serve as a major
communicator to alert the cell to the changing environment. In response to stresses …

[HTML][HTML] Ionizing radiation and chemical oxidant exposure impacts on Cryptococcus neoformans transfer RNAs

M Kelley, MJ Paulines, G Yoshida, R Myers, M Jora… - PloS one, 2022 - journals.plos.org
Cryptococcus neoformans is a fungus that is able to survive abnormally high levels of
ionizing radiation (IR). The radiolysis of water by IR generates reactive oxygen species …