Temperature influences the structural and functional properties of cellular components,
necessitating stress responses to restore homeostasis following temperature shift. Whereas …

Cryptococcus neoformans is a human fungal pathogen that survives exposure to stresses
during growth in the human host, including oxidative and nitrosative stress, high …

Cryptococcus neoformans is a ubiquitous free-living soil yeast. It is also an opportunistic
pathogen that causes about 223,100 cases of cryptococcal meningitis per year, resulting in …

Cryptococcus gattii is a human and animal pathogen that infects healthy hosts and caused
the Pacific Northwest outbreak of cryptococcosis. The inhalation of infectious propagules …

The phenotypic plasticity of Cryptococcus neoformans is widely studied and demonstrated in
vitro, but its influence on pathogenicity remains unclear. In this study, we investigated the …

The human pathogen Cryptococcus neoformans, which causes life-threatening
meningoencephalitis in immunocompromised individuals, normally faces diverse stresses in …

Sensing, responding, and adapting to the surrounding environment are crucial for all living
organisms to survive, proliferate, and differentiate in their biological niches. This ability is …

Stress-induced adaptations require multiple levels of regulation in all organisms to repair
cellular damage. In the present study we evaluated the genome-wide transcriptional and …

The ability of the fungal pathogen Cryptococcus neoformans to evade the mammalian innate
immune response and cause disease is partially due to its ability to respond to and survive …

Adaptation to external environmental challenges at the cellular level requires rapid
responses and involves relay of information to the nucleus to drive key gene expression …