Myelin loss is associated with axonal damage in established multiple sclerosis. This
relationship is challenging to study in vivo in early disease. Here, we ask whether myelin …

Damage to the myelin sheath and the neuroaxonal unit is a cardinal feature of multiple
sclerosis; however, a detailed characterization of the interaction between myelin and axon …

The myelin concentration and the degree of myelination of nerve fibers can provide valuable
information on the integrity of human brain tissue. Magnetic resonance imaging (MRI) of …

Objective Magnetic resonance imaging (MRI) is essential for multiple sclerosis diagnostics
but is conventionally not specific to demyelination. Myelin imaging is often hampered by …

Purpose We hypothesize that myelin is more susceptible to damage over time than axons.
We investigated the association between the estimated duration from the onset of multiple …

BACKGROUND AND PURPOSE: Myelin and axon volume fractions can now be estimated
via MR imaging in vivo, as can the g-ratio, which equals the ratio of the inner to the outer …

Introduction Quantitative microstructural MRI, such as myelin-sensitive magnetisation
transfer ratio (MTR) or saturation (MTsat), axon-sensitive water diffusion Neurite Orientation …

Different MRI techniques are used to investigate multiple sclerosis (MS) in vivo. The
pathological specificity of these techniques is poorly understood, in particular their …

BACKGROUND AND PURPOSE: A number of MR-derived quantitative metrics have been
suggested to assess the pathophysiology of MS, but the reports about combined analyses of …

Quantitative magnetic resonance imaging (MRI) techniques have been developed as
imaging biomarkers, aiming to improve the specificity of MRI to underlying pathology …