[PDF][PDF] Lack of cocaine effect on dopamine clearance in the core and shell of the nucleus accumbens of dopamine transporter knock-out mice
EA Budygin, CE John, Y Mateo… - The Journal of …, 2002 - Soc Neuroscience
Cocaine produces its reinforcing effects primarily by inhibiting the dopamine transporter
(DAT) at the level of presynaptic terminals and increasing extracellular levels of dopamine …
(DAT) at the level of presynaptic terminals and increasing extracellular levels of dopamine …
Voltammetric assessment of dopamine clearance in the absence of the dopamine transporter: no contribution of other transporters in core or shell of nucleus …
Y Mateo, EA Budygin, CE John, ML Banks… - Journal of neuroscience …, 2004 - Elsevier
Cocaine elevates dopamine (DA) in the nucleus accumbens (NAc) by blocking the uptake of
DA through the DA transporter (DAT). It is commonly believed that the reinforcing properties …
DA through the DA transporter (DAT). It is commonly believed that the reinforcing properties …
Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter
R Chen, MR Tilley, H Wei, F Zhou… - Proceedings of the …, 2006 - National Acad Sciences
There are three known high-affinity targets for cocaine: the dopamine transporter (DAT), the
serotonin transporter (SERT), and the norepinephrine transporter (NET). Decades of studies …
serotonin transporter (SERT), and the norepinephrine transporter (NET). Decades of studies …
[PDF][PDF] Cocaine and amphetamine increase extracellular dopamine in the nucleus accumbens of mice lacking the dopamine transporter gene
E Carboni, C Spielewoy, C Vacca… - The Journal of …, 2001 - Soc Neuroscience
Behavioral and biochemical studies suggest that dopamine (DA) plays a role in the
reinforcing and addictive properties of drugs of abuse. Recently, this hypothesis has been …
reinforcing and addictive properties of drugs of abuse. Recently, this hypothesis has been …
[HTML][HTML] Cocaine reward and locomotion stimulation in mice with reduced dopamine transporter expression
MR Tilley, B Cagniard, X Zhuang, DD Han, N Tiao… - BMC neuroscience, 2007 - Springer
Background The dopamine transporter (DAT) plays a critical role in regulating dopamine
neurotransmission. Variations in DAT or changes in basal dopaminergic tone have been …
neurotransmission. Variations in DAT or changes in basal dopaminergic tone have been …
Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines
Selective blockers of the norepinephrine transporter (NET) inhibit dopamine uptake in the
prefrontal cortex. This suggests that dopamine in this region is normally cleared by the …
prefrontal cortex. This suggests that dopamine in this region is normally cleared by the …
Altered dopamine transporter function and phosphorylation following chronic cocaine self-administration and extinction in rats
S Ramamoorthy, DJ Samuvel… - Biochemical and …, 2010 - Elsevier
Cocaine binds with the dopamine transporter (DAT), an effect that has been extensively
implicated in its reinforcing effects. However, persisting adaptations in DAT regulation after …
implicated in its reinforcing effects. However, persisting adaptations in DAT regulation after …
Dysregulation of dopamine transporter trafficking and function after abstinence from cocaine self-administration in rats: evidence for differential regulation in caudate …
DJ Samuvel, LD Jayanthi, S Manohar… - … of Pharmacology and …, 2008 - ASPET
The profound alterations produced by cocaine on dopamine (DA) neurotransmission raise
the possibility that dopamine transporter (DAT)-expressing neurons may modify DA transport …
the possibility that dopamine transporter (DAT)-expressing neurons may modify DA transport …
Stimulant and reinforcing effects of cocaine in monoamine transporter knockout mice
BA Rocha - European journal of pharmacology, 2003 - Elsevier
A large body of evidence supports the hypothesis that the reinforcing effects of cocaine
depend on its ability to block the dopamine transporter (DAT), thereby increasing dopamine …
depend on its ability to block the dopamine transporter (DAT), thereby increasing dopamine …
Mice expressing markedly reduced striatal dopamine transporters exhibit increased locomotor activity, dopamine uptake turnover rate, and cocaine responsiveness
A Rao, A Sorkin, NR Zahniser - Synapse, 2013 - Wiley Online Library
Variations in the expression levels of the dopamine transporter (DAT) can influence
responsiveness to psychostimulant drugs like cocaine. To better understand this …
responsiveness to psychostimulant drugs like cocaine. To better understand this …