Review of drug development guidance to treat chronic obstructive pulmonary disease: US and EU perspectives

A van Haarst, L McGarvey… - Clinical Pharmacology & …, 2019 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) remains a leading cause of death
worldwide, yet only one new drug class has been approved in the last decade. However …

Current controversies in the pharmacological treatment of chronic obstructive pulmonary disease

D Singh, N Roche, D Halpin, A Agusti… - American journal of …, 2016 - atsjournals.org
Clinical phenotyping is currently used to guide pharmacological treatment decisions in
chronic obstructive pulmonary disease (COPD), a personalized approach to care. Precision …

Pharmacological treatment of chronic obstructive pulmonary disease: from evidence-based medicine to phenotyping

P Montuschi, M Malerba, G Santini, M Miravitlles - Drug discovery today, 2014 - Elsevier
Highlights•Several phenotypes characterize chronic obstructive pulmonary disease
(COPD).•Response to pharmacological treatment in COPD is highly variable.•Guidelines …

An update on outcomes for COPD pharmacological trials: a COPD investigators report-reassessment of the 2008 American Thoracic Society/European Respiratory …

M Cazzola, P Rogliani, PJ Barnes, F Blasi… - American Journal of …, 2023 - atsjournals.org
Background: In 2008, a dedicated American Thoracic Society/European Respiratory Society
task force published a paper on the possible use and limitations of clinical outcomes and …

An overview of the current management of chronic obstructive pulmonary disease: can we go beyond the GOLD recommendations?

M Cazzola, P Rogliani, E Puxeddu, J Ora… - Expert review of …, 2018 - Taylor & Francis
Introduction: Treatment recommendations are based on randomized controlled trials (RCTs).
However, only about 1 in 20 people meet the inclusion criteria for RCTs forming consensus …

Optimizing management of chronic obstructive pulmonary disease in the upcoming decade

R Russell, A Anzueto, I Weisman - International Journal of Chronic …, 2011 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is a leading cause of disability and mortality.
Caring for patients with COPD, particularly those with advanced disease who experience …

The future of chronic obstructive pulmonary disease treatment—difficulties of and barriers to drug development

FJ Martinez, JF Donohue, SI Rennard - The Lancet, 2011 - thelancet.com
Although chronic obstructive pulmonary disease (COPD) is a major global health problem
with a rising incidence and morbidity, few pharmacotherapeutic advances have been made …

[HTML][HTML] Pharmacological treatment and current controversies in COPD

M Cazzola, P Rogliani, D Stolz, MG Matera - F1000Research, 2019 - ncbi.nlm.nih.gov
Bronchodilators, corticosteroids, and antibiotics are still key elements for treating chronic
obstructive pulmonary disease in the 2019 Global Initiative for Chronic Obstructive Lung …

Chronic obstructive pulmonary disease treatment and pharmacist-led medication management

LC Li, YY Han, ZH Zhang, WC Zhou… - Drug Design …, 2021 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death across
the globe. Its repeated exacerbation will seriously worsen the quality of life, aggravate the …

Outcomes for COPD pharmacological trials: from lung function to biomarkers

M Cazzola, W MacNee, FJ Martinez… - European respiratory …, 2008 - Eur Respiratory Soc
The American Thoracic Society/European Respiratory Society jointly created a Task Force
on “Outcomes for COPD pharmacological trials: from lung function to biomarkers” to inform …