[HTML][HTML] The CD8 T cell-Epstein-Barr virus-B cell trialogue: a central issue in multiple sclerosis pathogenesis

C Veroni, F Aloisi - Frontiers in immunology, 2021 - frontiersin.org
The cause and the pathogenic mechanisms leading to multiple sclerosis (MS), a chronic
inflammatory disease of the central nervous system (CNS), are still under scrutiny. During …

Epstein-Barr virus-specific CD8 T cells selectively infiltrate the brain in multiple sclerosis and interact locally with virus-infected cells: clue for a virus-driven …

B Serafini, B Rosicarelli, C Veroni, GA Mazzola… - Journal of …, 2019 - Am Soc Microbiol
Epstein-Barr virus (EBV) is a ubiquitous herpesvirus strongly associated with multiple
sclerosis (MS), a chronic inflammatory disease of the central nervous system (CNS) …

Defective T‐cell control of Epstein–Barr virus infection in multiple sclerosis

MP Pender, PA Csurhes, JM Burrows… - Clinical & …, 2017 - Wiley Online Library
Mounting evidence indicates that infection with Epstein–Barr virus (EBV) has a major role in
the pathogenesis of multiple sclerosis (MS). Defective elimination of EBV‐infected B cells by …

[HTML][HTML] Altered immune response to the epstein–barr virus as a prerequisite for multiple sclerosis

F Läderach, C Münz - Cells, 2022 - mdpi.com
Strong epidemiologic evidence links Epstein–Barr virus (EBV) infection and its altered
immune control to multiple sclerosis (MS) development. Clinical MS onset occurs years after …

Translational mini-review series on B cell subsets in disease. B cells in multiple sclerosis: drivers of disease pathogenesis and Trojan horse for Epstein–Barr virus …

UC Meier, G Giovannoni, JS Tzartos… - Clinical & Experimental …, 2012 - academic.oup.com
Summary OTHER ARTICLES PUBLISHED IN THIS MINI-REVIEW SERIES ON B CELL
SUBSETS IN DISEASE Transitional B cells in systemic lupus erythematosus and Sjögren's …

[HTML][HTML] Epstein–Barr virus in multiple sclerosis: theory and emerging immunotherapies

A Bar-Or, MP Pender, R Khanna, L Steinman… - Trends in molecular …, 2020 - cell.com
New treatments for multiple sclerosis (MS) focused on B cells have created an atmosphere
of excitement in the MS community. B cells are now known to play a major role in disease …

[HTML][HTML] B and T cells driving multiple sclerosis: identity, mechanisms and potential triggers

J Van Langelaar, L Rijvers, J Smolders… - Frontiers in …, 2020 - frontiersin.org
Historically, multiple sclerosis (MS) has been viewed as being primarily driven by T cells.
However, the effective use of anti-CD20 treatment now also reveals an important role for B …

Epstein–Barr virus and multiple sclerosis: potential opportunities for immunotherapy

MP Pender, SR Burrows - Clinical & translational immunology, 2014 - Wiley Online Library
Multiple sclerosis (MS) is a common chronic inflammatory demyelinating disease of the
central nervous system (CNS) causing progressive disability. Many observations implicate …

[HTML][HTML] Multiple sclerosis and T lymphocytes: an entangled story

L Legroux, N Arbour - Journal of Neuroimmune Pharmacology, 2015 - Springer
Multiple sclerosis (MS) is the prototypic inflammatory disease of the central nervous system
(CNS) characterized by multifocal areas of demyelination, axonal damage, activation of glial …

[HTML][HTML] The enigmatic role of viruses in multiple sclerosis: molecular mimicry or disturbed immune surveillance?

J Geginat, M Paroni, M Pagani, D Galimberti… - Trends in …, 2017 - cell.com
Multiple sclerosis (MS) is a T cell driven autoimmune disease of the central nervous system
(CNS). Despite its association with Epstein-Barr Virus (EBV), how viral infections promote …