[HTML][HTML] The CD8 T cell-Epstein-Barr virus-B cell trialogue: a central issue in multiple sclerosis pathogenesis

C Veroni, F Aloisi - Frontiers in immunology, 2021 - frontiersin.org
The cause and the pathogenic mechanisms leading to multiple sclerosis (MS), a chronic
inflammatory disease of the central nervous system (CNS), are still under scrutiny. During …

Epstein-Barr virus-specific CD8 T cells selectively infiltrate the brain in multiple sclerosis and interact locally with virus-infected cells: clue for a virus-driven …

B Serafini, B Rosicarelli, C Veroni, GA Mazzola… - Journal of …, 2019 - Am Soc Microbiol
Epstein-Barr virus (EBV) is a ubiquitous herpesvirus strongly associated with multiple
sclerosis (MS), a chronic inflammatory disease of the central nervous system (CNS) …

Defective T‐cell control of Epstein–Barr virus infection in multiple sclerosis

MP Pender, PA Csurhes, JM Burrows… - Clinical & …, 2017 - Wiley Online Library
Mounting evidence indicates that infection with Epstein–Barr virus (EBV) has a major role in
the pathogenesis of multiple sclerosis (MS). Defective elimination of EBV‐infected B cells by …

[HTML][HTML] Altered immune response to the epstein–barr virus as a prerequisite for multiple sclerosis

F Läderach, C Münz - Cells, 2022 - mdpi.com
Strong epidemiologic evidence links Epstein–Barr virus (EBV) infection and its altered
immune control to multiple sclerosis (MS) development. Clinical MS onset occurs years after …

[HTML][HTML] Epstein–Barr virus in multiple sclerosis: theory and emerging immunotherapies

A Bar-Or, MP Pender, R Khanna, L Steinman… - Trends in molecular …, 2020 - cell.com
New treatments for multiple sclerosis (MS) focused on B cells have created an atmosphere
of excitement in the MS community. B cells are now known to play a major role in disease …

[HTML][HTML] B and T cells driving multiple sclerosis: identity, mechanisms and potential triggers

J Van Langelaar, L Rijvers, J Smolders… - Frontiers in …, 2020 - frontiersin.org
Historically, multiple sclerosis (MS) has been viewed as being primarily driven by T cells.
However, the effective use of anti-CD20 treatment now also reveals an important role for B …

Epstein–Barr virus and multiple sclerosis: potential opportunities for immunotherapy

MP Pender, SR Burrows - Clinical & translational immunology, 2014 - Wiley Online Library
Multiple sclerosis (MS) is a common chronic inflammatory demyelinating disease of the
central nervous system (CNS) causing progressive disability. Many observations implicate …

Multiple sclerosis and T lymphocytes: an entangled story

L Legroux, N Arbour - Journal of Neuroimmune Pharmacology, 2015 - Springer
Multiple sclerosis (MS) is the prototypic inflammatory disease of the central nervous system
(CNS) characterized by multifocal areas of demyelination, axonal damage, activation of glial …

[HTML][HTML] The enigmatic role of viruses in multiple sclerosis: molecular mimicry or disturbed immune surveillance?

J Geginat, M Paroni, M Pagani, D Galimberti… - Trends in …, 2017 - cell.com
Multiple sclerosis (MS) is a T cell driven autoimmune disease of the central nervous system
(CNS). Despite its association with Epstein-Barr Virus (EBV), how viral infections promote …

Epstein–Barr virus and multiple sclerosis: moving from questions of association to questions of mechanism

OG Thomas, A Rickinson… - Clinical & Translational …, 2023 - Wiley Online Library
Abstract The link between Epstein–Barr virus (EBV) and multiple sclerosis (MS) has puzzled
researchers since it was first discovered over 40 years ago. Until that point, EBV was …