Attenuated immune control of Epstein–Barr virus in humanized mice is associated with the multiple sclerosis risk factor HLA‐DR15

H Zdimerova, A Murer, C Engelmann… - European journal of …, 2021 - Wiley Online Library
Abstract Immune responses to Epstein–Barr virus (EBV) infection synergize with the main
genetic risk factor HLA‐DRB1* 15: 01 (HLA‐DR15) to increase the likelihood to develop the …

Increased frequency and broadened specificity of latent EBV nuclear antigen-1-specific T cells in multiple sclerosis

JD Lünemann, N Edwards, PA Muraro, S Hayashi… - Brain, 2006 - academic.oup.com
Epidemiological studies consistently demonstrate that patients with multiple sclerosis are
almost universally infected with Epstein–Barr virus (EBV) and that the risk of developing the …

Intrathecal CD8 T-cells of multiple sclerosis patients recognize lytic Epstein-Barr virus proteins

GP van Nierop, J Mautner… - Multiple Sclerosis …, 2016 - journals.sagepub.com
Background: The association between Epstein-Barr virus (EBV) and multiple sclerosis (MS)
may involve intrathecal EBV-specific T-cell responses targeting the virus or indirectly …

Preventing and curing multiple sclerosis by controlling Epstein–Barr virus infection

MP Pender - Autoimmunity reviews, 2009 - Elsevier
It has been noted since 1981 that late primary infection with the Epstein–Barr virus (EBV) in
adolescence or young adulthood can account for the epidemiology of multiple sclerosis …

Multiple sclerosis–a response-to-damage model

BA't Hart, RQ Hintzen, JD Laman - Trends in molecular medicine, 2009 - cell.com
According to a widely supported but unproven concept, the autoimmune mechanisms that
drive neuroinflammation in multiple sclerosis (MS) are triggered by virus infection. However …

Epstein-Barr virus infection of human brain microvessel endothelial cells: a novel role in multiple sclerosis

C Casiraghi, K Dorovini-Zis, MS Horwitz - Journal of neuroimmunology, 2011 - Elsevier
Multiple sclerosis (MS) is an inflammatory neurological disease that is widely regarded as
the outcome of complex interactions between a genetic predisposition and an environmental …

[HTML][HTML] Pathogenic T cell cytokines in multiple sclerosis

CA Wagner, PJ Roqué, JM Goverman - Journal of Experimental …, 2020 - rupress.org
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous
system that is believed to have an autoimmune etiology. As MS is the most common …

The CD4–Th1 model for multiple sclerosis: a crucial re-appraisal

H Lassmann, RM Ransohoff - Trends in immunology, 2004 - cell.com
Multiple sclerosis (MS), an acquired spontaneous chronic inflammatory demyelinating
disease of the human central nervous system (CNS) has features of autoimmunity to myelin …

Viral pathophysiology of multiple sclerosis: A role for Epstein-Barr virus infection?

AH Maghzi, M Marta, I Bosca, M Etemadifar, R Dobson… - Pathophysiology, 2011 - Elsevier
Multiple sclerosis (MS) is the most common inflammatory demyelinating and degenerative
disease of the CNS. The cause of MS is unknown but environmental risk factors are …

Immune regulation of multiple sclerosis by CD8+ T cells

S Sinha, FR Itani, NJ Karandikar - Immunologic research, 2014 - Springer
The role of CD8+ T cells in the process of autoimmune pathology has been both
understudied and controversial. Multiple sclerosis (MS) is an inflammatory, demyelinating …