Current clinical phenomenological diagnosis in psychiatry neither captures biologically
homologous disease entities nor allows for individualized treatment prescriptions based on …

Objective: Clinical phenomenology remains the primary means for classifying psychoses
despite considerable evidence that this method incompletely captures biologically …

Background Psychiatry aspires to the molecular understanding of its disorders and, with that
knowledge, to precision medicine. Research supporting such goals in the dimension of …

Bipolar and schizophrenia network for intermediate phenotypes is a network of investigator-
driven laboratories focused on developing phenotypes, genotypes, and biomarkers for …

Using machine learning, we recently decomposed the neuroanatomical heterogeneity of
established schizophrenia to discover two volumetric subgroups—a 'lower brain …

Background Endophenotypes are quantitative, laboratory-based measures representing
intermediate links in the pathways between genetic variation and the clinical expression of a …

It is critical for psychiatry as a field to develop approaches to define the molecular, cellular,
and circuit basis of its brain diseases, especially for serious mental illnesses, and then to …

Focusing on biomarker identification and using biomarkers individually or in clusters to
define biological subgroups in psychiatry requires a re-orientation from behavioral …

Background Recently, a biologically-driven psychosis classification (B-SNIP Biotypes) was
derived using brain-based cognitive and electrophysiological markers. Here, we …

Traditional diagnostic formulations of psychotic disorders have low correspondence with
underlying disease neurobiology. This has led to a growing interest in using brain-based …