TRPV1 has been originally cloned as the heat and capsaicin receptor implicated in acute
pain signalling, while further research has shifted the focus to its importance in chronic pain …

TRPV1 is a non-selective cation channel gated by noxious heat, vanilloids and extracellular
protons, and act as an important signal integrator in sensory nociceptors. Because of its …

The transient receptor potential vanilloid type 1 ion channel (TRPV1) was identified as a
receptor responsible for mediating the intense burning sensation following exposure to heat …

Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel that is
intensively expressed in the peripheral nerve system and involved in a variety of …

Neurogenic inflammation is produced by overstimulation of peripheral nociceptor terminals
by injury or inflammation of tissues. Excessive activity of sensory neurons produces …

Patients with inflammatory or neuropathic pain experience hypersensitivity to mechanical,
thermal and/or chemical stimuli. Given the diverse etiologies and molecular mechanisms of …

Neuropathic pain is a debilitating disease which affects central as well as peripheral
nervous system. Transient receptor potential (TRP) channels are ligand-gated ion channels …

Preclinical research has identified an array of ion channels in sensory neurons involved in
the generation and transduction of pain as potential targets for pharmacological intervention …

Historically, drug research targeted to pain treatment has focused on trying to prevent the
propagation of action potentials in the periphery from reaching the brain rather than …

The transient receptor potential vanilloid 1 and ankyrin 1 (TRPV1 and TRPA1, respectively)
channels are members of the TRP superfamily of structurally related, non‐selective cation …