The functions of TRPA1 and TRPV1: moving away from sensory nerves

ES Fernandes, MA Fernandes… - British journal of …, 2012 - Wiley Online Library
The transient receptor potential vanilloid 1 and ankyrin 1 (TRPV1 and TRPA1, respectively)
channels are members of the TRP superfamily of structurally related, non‐selective cation …

Pleiotropic function of TRPV4 ion channels in the central nervous system

P Kanju, W Liedtke - Experimental physiology, 2016 - Wiley Online Library
New Findings What is the topic of this review? In this concise review, we highlight insights
into the role of transient receptor potential, vanilloid type 4 (TRPV4) ion channels in the …

The role of TRPA1 in visceral inflammation and pain

TK Lapointe, C Altier - Channels, 2011 - Taylor & Francis
Despite significant progress in our understanding of the cellular and molecular mechanisms
underlying sensory transduction and nociception, clinical pain management remains a …

TRP channels in nociception and pathological pain

CY Hung, CH Tan - Advances in pain research: mechanisms and …, 2018 - Springer
Thermal and noxious stimuli are detected by specialized nerve endings, which transform the
stimuli into electrical signals and transmit the signals into central nervous system to facilitate …

TRPV1 in the central nervous system: synaptic plasticity, function, and pharmacological implications

JG Edwards - Capsaicin as a therapeutic molecule, 2014 - Springer
The function of TRPV1 in the peripheral nervous system is increasingly being investigated
for its anti-inflammatory and antinociceptive properties in an effort to find a novel target to …

TRP channels role in pain associated with neurodegenerative diseases

M Duitama, V Vargas-López, Z Casas… - Frontiers in …, 2020 - frontiersin.org
Transient receptor potential (TRP) are cation channels expressed in both non-excitable and
excitable cells from diverse tissues, including heart, lung, and brain. The TRP channel family …

Peripheral TRPV1 receptors as targets for drug development: new molecules and mechanisms

A Szallasi, MJ Gunthorpe - Current pharmaceutical design, 2008 - ingentaconnect.com
Based on the painful effects of exposure to capsaicin, TRPV1 (transient receptor potential
vanilloid subfamily member 1) lo-calization is most readily associated with peripheral …

Capsaicin receptor: TRPV1 a promiscuous TRP channel

SC Pingle, JA Matta, GP Ahern - Transient Receptor Potential (TRP) …, 2007 - Springer
TRPV1, the archetypal member of the vanilloid TRP family, was initially identified as the
receptor for capsaicin, the pungent ingredient in hot chili peppers. The receptor has a …

Modulation of the TRPV1 channel: current clinical trials and recent patents with focus on neurological conditions

L De Petrocellis, AS Moriello - Recent Patents on CNS Drug …, 2013 - ingentaconnect.com
The transient receptor potential vanilloid-1 cat ion channel (TRPV1) is a nonspecific cation
channel that can be activated by multiple endogenous stimuli and is expressed …

TRPs in pain sensation

I Jardín, JJ López, R Diez, J Sánchez-Collado… - Frontiers in …, 2017 - frontiersin.org
According to the International Association for the Study of Pain (IASP) pain is characterized
as an “unpleasant sensory and emotional experience associated with actual or potential …