TRP channels as emerging targets for pain therapeutics
LM Broad, AJ Mogg, RE Beattie… - Expert opinion on …, 2009 - Taylor & Francis
Background: The transient receptor potential (TRP) superfamily of ion channels are a large
and diverse group that have received increased attention in recent years. The sub-family of …
and diverse group that have received increased attention in recent years. The sub-family of …
TRPV1 receptor: a target for the treatment of pain, cough, airway disease and urinary incontinence.
Y Jia, RL McLeod, JA Hey - Drug news & perspectives, 2005 - europepmc.org
The TRPV1 channel is mainly expressed in sensory nerves. Activation of the channel
induces neuropeptide release from central and peripheral sensory nerve terminals, resulting …
induces neuropeptide release from central and peripheral sensory nerve terminals, resulting …
[HTML][HTML] Beyond neuronal heat sensing: diversity of TRPV1 heat-capsaicin receptor-channel functions
YM Shuba - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
Transient receptor potential vanilloid 1 (TRPV1) is a calcium-permeable ion channel best
known for its ability to be gated by the pungent constituent of red chili pepper, capsaicin, and …
known for its ability to be gated by the pungent constituent of red chili pepper, capsaicin, and …
TRPV1 receptors in the central nervous system: potential for previously unforeseen therapeutic applications
Increasing evidence exists to support the presence of functional transient receptor potential
vanilloid type 1 (TRPV1) channels in the brain, where these receptors are unlikely to be …
vanilloid type 1 (TRPV1) channels in the brain, where these receptors are unlikely to be …
[HTML][HTML] Physiological significance of TRPV2 as a mechanosensor, thermosensor and lipid sensor
K Shibasaki - The journal of physiological sciences, 2016 - Springer
This review provides a summary of the physiological significance of the TRPV2 ion channel.
While TRPV2 was initially characterized as a noxious heat sensor, we found that TRPV2 can …
While TRPV2 was initially characterized as a noxious heat sensor, we found that TRPV2 can …
TRPV1 and synaptic transmission
JA Matta, GP Ahern - Current pharmaceutical biotechnology, 2011 - ingentaconnect.com
Transient Receptor Potential Vanilloid Type 1 is a prominent “pain” receptor expressed in
sensory afferent neurons. TRPV1 on peripheral nerve terminals detects a variety of noxious …
sensory afferent neurons. TRPV1 on peripheral nerve terminals detects a variety of noxious …
The role of endogenous molecules in modulating pain through transient receptor potential vanilloid 1 (TRPV1)
SL Morales‐Lázaro, SA Simon… - The Journal of …, 2013 - Wiley Online Library
Key points• TRPV1 (transient receptor potential vanilloid 1) channels are found throughout
the body in epithelial cells and in peripheral and central terminals in neurons. They exert a …
the body in epithelial cells and in peripheral and central terminals in neurons. They exert a …
Therapeutic targeting of TRP channels-the TR (i) P to pain relief
SR Eid - Current topics in medicinal chemistry, 2011 - ingentaconnect.com
Following the cloning and characterization of the transient receptor potential vanilloid 1
(TRPV1), a growing body of research has identified the important role of TRPV1 and related …
(TRPV1), a growing body of research has identified the important role of TRPV1 and related …