TRPV1 antagonists as a potential treatment for hyperalgesia
LA Roberts, M Connor - Recent Patents on CNS Drug …, 2006 - ingentaconnect.com
The vanilloid receptor (TRPV1) is a member of the transient receptor potential family of ion
channels that is highly expressed in nociceptive primary afferent sensory neurons. TRPV1 is …
channels that is highly expressed in nociceptive primary afferent sensory neurons. TRPV1 is …
TRP channels and analgesia
LS Premkumar, M Abooj - Life sciences, 2013 - Elsevier
Since cloning and characterizing the first nociceptive ion channel Transient Receptor
Potential (TRP) Vanilloid 1 (TRPV1), other TRP channels involved in nociception have been …
Potential (TRP) Vanilloid 1 (TRPV1), other TRP channels involved in nociception have been …
Complex regulation of TRPV1 and related thermo-TRPs: implications for therapeutic intervention
R Planells-Cases, P Valente, A Ferrer-Montiel… - Transient Receptor …, 2011 - Springer
The capsaicin receptor TRPV1 (T ransient R eceptor P otential, V anilloid family member 1),
the founding member of the heat-sensitive TRP (“thermo-TRP”) channel family, plays a …
the founding member of the heat-sensitive TRP (“thermo-TRP”) channel family, plays a …
TRPV1 antagonists as analgesic agents
M Trevisani, R Gatti - The Open Pain Journal, 2013 - benthamopen.com
Abstract The last decade (2001-2010), declared as the Decade of Pain Control and
Research by the United States Congress, brought significantly advances in our …
Research by the United States Congress, brought significantly advances in our …
TRPV4 agonists and antagonists
F Vincent, M AJ Duncton - Current topics in medicinal chemistry, 2011 - ingentaconnect.com
TRPV4 belongs to the TRPV subfamily of Transient Receptor Potential (TRP) ion channels.
This year marks the 10 year anniversary of the discovery of this polymodal ion channel …
This year marks the 10 year anniversary of the discovery of this polymodal ion channel …
TRPV1: a therapeutic target for novel analgesic drugs?
A Szallasi, F Cruz, P Geppetti - Trends in molecular medicine, 2006 - cell.com
The vanilloid receptor TRPV1 is now recognized as a molecular integrator of painful stimuli
ranging from noxious heat to endovanilloids in inflammation. Pharmacological blockade of …
ranging from noxious heat to endovanilloids in inflammation. Pharmacological blockade of …
[HTML][HTML] TRPV1 channel: a noxious signal transducer that affects mitochondrial function
R Juárez-Contreras, KA Méndez-Reséndiz… - International Journal of …, 2020 - mdpi.com
The Transient Receptor Vanilloid 1 (TRPV1) or capsaicin receptor is a nonselective cation
channel, which is abundantly expressed in nociceptors. This channel is an important …
channel, which is abundantly expressed in nociceptors. This channel is an important …
Transient receptor potential channels in neuropathic pain
L Basso, C Altier - Current opinion in pharmacology, 2017 - Elsevier
Highlights•Neuropathic pain is a chronic condition that represents a major health
problem.•There is a need for new medications with greater efficacy and less adverse …
problem.•There is a need for new medications with greater efficacy and less adverse …
TRPV1 shows dynamic ionic selectivity during agonist stimulation
Transient receptor potential vanilloid 1 (TRPV1) is an ion channel that is gated by noxious
heat, capsaicin and other diverse stimuli. It is a nonselective cation channel that prefers …
heat, capsaicin and other diverse stimuli. It is a nonselective cation channel that prefers …
Modulation of the TRPV4 ion channel as a therapeutic target for disease
Abstract Transient Receptor Potential Vanilloid 4 (TRPV4) is a broadly expressed,
polymodally gated ion channel that plays an important role in many physiological and …
polymodally gated ion channel that plays an important role in many physiological and …