TRPV4: molecular conductor of a diverse orchestra
Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
TRPV1 antagonists: the challenges for therapeutic targeting
N Khairatkar-Joshi, A Szallasi - Trends in molecular medicine, 2009 - cell.com
The capsaicin receptor TRPV1 (transient receptor potential cation channel, subfamily V,
member 1) is a polymodal nociceptor whose expression is upregulated in several painful …
member 1) is a polymodal nociceptor whose expression is upregulated in several painful …
Selective role for TRPV4 ion channels in visceral sensory pathways
Background & Aims: Although there are many candidates as molecular
mechanotransducers, so far there has been no evidence for molecular specialization of …
mechanotransducers, so far there has been no evidence for molecular specialization of …
TRP channel cooperation for nociception: therapeutic opportunities
D Bamps, J Vriens, J de Hoon… - Annual Review of …, 2021 - annualreviews.org
Chronic pain treatment remains a sore challenge, and in our aging society, the number of
patients reporting inadequate pain relief continues to grow. Current treatment options all …
patients reporting inadequate pain relief continues to grow. Current treatment options all …
Quantification of TRPV1 protein levels in rat tissues to understand its physiological roles
P Han, AV Korepanova, MH Vos, RB Moreland… - Journal of Molecular …, 2013 - Springer
Transient receptor potential subfamily V, member 1 (TRPV1) is a nonselective cation
channel expressed in both the peripheral and central nervous systems (CNS). TRPV1 …
channel expressed in both the peripheral and central nervous systems (CNS). TRPV1 …
Modulation of TRPV1 channel function by natural products in the treatment of pain
MA Abbas - Chemico-biological interactions, 2020 - Elsevier
The capsaicin (vanilloid) receptor, TRPV1, is a heat-activated cation channel modulated by
inflammatory mediators and contributes to acute and chronic pain. TRPV1 channel is one of …
inflammatory mediators and contributes to acute and chronic pain. TRPV1 channel is one of …
The vanilloid receptor TRPV1: role in cardiovascular and gastrointestinal protection
J Peng, YJ Li - European journal of pharmacology, 2010 - Elsevier
It has been shown that the transient receptor potential channel vanilloid type 1 (TRPV1) is
able to sense a vast range of stimuli and exerts multiple functions under physiological or …
able to sense a vast range of stimuli and exerts multiple functions under physiological or …
The TRPV1 receptor and nociception
DC Immke, NR Gavva - Seminars in cell & developmental biology, 2006 - Elsevier
The capsaicin receptor TRPV1 is an emerging target for the treatment of pain with a unique
expression profile in peripheral nociceptors and the ability to show polymodal activation …
expression profile in peripheral nociceptors and the ability to show polymodal activation …
Polymodal transient receptor potential vanilloid type 1 nocisensor: structure, modulators, and therapeutic applications
Transient receptor potential (TRP) channels belong to a superfamily of sensory-related ion
channels responding to a wide variety of thermal, mechanical, or chemical stimuli. In an …
channels responding to a wide variety of thermal, mechanical, or chemical stimuli. In an …
TRPV1 channels in immune cells and hematological malignancies
Transient receptor potential vanilloid-1 (TRPV1) is a member of the TRP family of channels
that are responsible for nociceptive, thermal, and mechanical sensations. Originally …
that are responsible for nociceptive, thermal, and mechanical sensations. Originally …