Background African Americans have both a higher incidence of prostate cancer and greater
disease‐specific mortality compared with non‐Hispanic whites. Historically, the investigation …

PURPOSE In studies of men of European ancestry, rare pathogenic variants in DNA repair
pathway genes have been shown to be associated with risk of aggressive prostate cancer …

Simple Summary Identifying which men at the time of prostate cancer diagnosis have, or will
progress to, an aggressive fatal disease will allow clinicians to assist men in making better …

Studies of families who segregate BRCA2 mutations have found that men who carry disease-
associated mutations have an increased risk of prostate cancer, particularly early-onset …

BACKGROUND Prostate cancer has a significant heritable component, and rare deleterious
germline variants in certain genes can increase the risk of the disease. The aim of the …

Studies of families with breast cancer have indicated that male carriers of BRCA2 mutations
are at increased risk of prostate cancer, particularly at an early age. To evaluate the …

Background Mutations in several common hereditary cancer genes are associated with
prostate cancer, but there is limited information on the prevalence of these mutations in …

Background The goal of this study is to evaluate germline genetic variants in African
American men with metastatic prostate cancer as compared to those in Caucasian men with …

Background: Prostate cancer (PrCa) is one of the most common cancers affecting men but
its aetiology is poorly understood. Family history of PrCa, particularly at a young age, is a …

Recent data suggests that African American men (AAM) with prostate cancer (PCa) exhibit
genetic alterations in highly penetrant germline genes, as well as low penetrant single …