Locomotor activity, emotionality, sensori-motor gating, learning and memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease
TP O'Leary, AT Hussin, RK Gunn, RE Brown - Brain Research Bulletin, 2018 - Elsevier
Abstract The APPswe/PS1dE9 mouse (line 85) is a double transgenic model of Alzheimer's
disease (AD) with familial amyloid precursor protein and presenilin-1 mutations. These mice …
disease (AD) with familial amyloid precursor protein and presenilin-1 mutations. These mice …
Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model
C Hirata-Fukae, HF Li, HS Hoe, AJ Gray, SS Minami… - Brain research, 2008 - Elsevier
Epidemiological studies indicate that women have a higher risk of Alzheimer's disease (AD)
even after adjustment for age. Though transgenic mouse models of AD develop AD-related …
even after adjustment for age. Though transgenic mouse models of AD develop AD-related …
[HTML][HTML] Cognitive impairment in the 3xTg-AD mouse model of Alzheimer's disease is affected by Aβ-immunotherapy and cognitive stimulation
AR Roda, G Esquerda-Canals, J Martí-Clúa, S Villegas - Pharmaceutics, 2020 - mdpi.com
Clinical symptoms of Alzheimer's Disease (AD) include behavioral alterations and cognitive
impairment. These functional phenotypes early occur in triple-transgenic (3xTg-AD) mice …
impairment. These functional phenotypes early occur in triple-transgenic (3xTg-AD) mice …
A longitudinal study of behavioral deficits in an AβPP transgenic mouse model of Alzheimer's disease
D Havas, B Hutter-Paier, K Ubhi… - Journal of …, 2011 - content.iospress.com
Elucidating the age-dependent alterations in transgenic (Tg) mice overexpressing amyloid-β
protein precursor (AβPP) is important for understanding the pathogenesis of Alzheimer's …
protein precursor (AβPP) is important for understanding the pathogenesis of Alzheimer's …
Influence of genetic background on apathy-like behavior in triple transgenic AD mice
R Pardossi-Piquard, I Lauritzen, C Bauer… - Current Alzheimer …, 2016 - ingentaconnect.com
Apathy is an early and common neuropsychiatric syndrome in Alzheimer's disease (AD)
patients. In clinical trials, apathy is associated with decreased motor activity that can be …
patients. In clinical trials, apathy is associated with decreased motor activity that can be …
[HTML][HTML] Sex differences between neuronal loss and the early onset of amyloid deposits and behavioral consequences in 5xFAD transgenic mouse as a model for …
A promising direction in the research on Alzheimer's Disease (AD) is the identification of
biomarkers that better inform the disease progression of AD. However, the performance of …
biomarkers that better inform the disease progression of AD. However, the performance of …
A non-transgenic mouse model (icv-STZ mouse) of Alzheimer's disease: similarities to and differences from the transgenic model (3xTg-AD mouse)
Y Chen, Z Liang, J Blanchard, CL Dai, S Sun… - Molecular …, 2013 - Springer
Alzheimer's disease (AD) can be divided into sporadic AD (SAD) and familial AD (FAD).
Most AD cases are sporadic and result from multiple etiologic factors, including …
Most AD cases are sporadic and result from multiple etiologic factors, including …
Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice
We sought to determine if sex impacts the cognitive and neuropathological phenotype of the
3xTg-AD mice. We find that male and female 3xTg-AD mice show comparable impairments …
3xTg-AD mice. We find that male and female 3xTg-AD mice show comparable impairments …
Thy1‐hAPPLond/Swe+ mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function
M Faizi, PL Bader, N Saw, TVV Nguyen… - Brain and …, 2012 - Wiley Online Library
Abstract Alzheimer's disease (AD), the most common form of dementia, is an age‐
dependent progressive neurodegenerative disorder. β‐amyloid, a metabolic product of the …
dependent progressive neurodegenerative disorder. β‐amyloid, a metabolic product of the …
9R, the cholinesterase and amyloid beta aggregation dual inhibitor, as a multifunctional agent to improve cognitive deficit and neuropathology in the triple-transgenic …
Y Ju, KY Tam - Neuropharmacology, 2020 - Elsevier
Alzheimer's disease (AD) is the most common kind of dementia in the aging population
leading to great social and financial burdens in many countries around the world. For …
leading to great social and financial burdens in many countries around the world. For …