The increasing global burden of Alzheimer's disease (AD) and failure of conventional
treatments to stop neurodegeneration necessitates an alternative approach. Evidence of …

The most widely used mouse model of Alzheimer's disease is the Tg2576 (APPSWE) model.
While general agreement about their neuropathology prevails, disparate results concerning …

The 5XFAD mice are an early‐onset transgenic model of Alzheimer's disease (AD) in which
amyloid plaques are first observed between two and four months of age in the cortical layer …

After we could recently demonstrate a beneficial effect of environmental enrichment on AD-
like brain pathology in female TgCRND8 mice [Ambrée O, Leimer U, Herring A, Görtz N …

The most profound deficits observed in Alzheimer's disease (AD) are in domains of episodic
and working memory systems. Transgenic (Tg) mice expressing mutated human amyloid …

Alzheimer's disease (AD) is characterized by progressive cognitive decline and the
presence of aggregates of amyloid beta (plaques) and hyperphosphorylated tau (tangles) …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
decline in cognitive function associated with the neuropathological hallmarks amyloid β …

Behavioral characterization of Alzheimer's disease (AD) transgenic models over multiple
time points during aging has been largely inadequate, usually being limited to one or two …

3xTg-AD mutant mice are characterized by parenchymal Aβ plaques and neurofibrillary
tangles resembling those found in patients with Alzheimer's disease. The mutants were …

Motor problems occur early in some patients with Alzheimer's disease (AD) and as the
disease progresses many patients develop motor dysfunction. Motor dysfunction has been …