The triple transgenic mouse (3xTgAD), harboring human APPSwe, PS1M146V and
TauP301L genes, develops age-dependent forebrain intraneuronal Aβ and tau as well as …

The Tg2576 mouse model of excessive cerebral β-amyloid deposition is now more than a
decade old, yet consensus as to its exact characteristics and utility as a model of Alzheimer's …

Although the impacts of environmental enrichment (EE) in several genetic models of
Alzheimer's disease (AD) have been documented, the focus has remained predominantly on …

In this study, we investigated the long-term treatment of dantrolene on amyloid and tau
neuropathology, brain volume, and cognitive function in aged triple transgenic Alzheimer …

Early diagnosis and treatment of AD are critical for delaying its progression. The present
study, therefore, examined the cognitive status and neuropathological characteristics of 4 …

Previous findings indicate that the acquisition and consolidation of recognition memory
involves dopaminergic activity. Although dopamine deregulation has been observed in …

Alzheimer's disease (AD) is a progressively debilitating brain disorder pathologically defined
by extracellular amyloid plaques, intraneuronal neurofibrillary tangles, and synaptic …

Female sex is a leading risk factor for developing Alzheimer's disease (AD). Sexual
dimorphism in AD is gaining attention as clinical data show that women are not only more …

Alzheimer's disease (AD) is the most common neurodegenerative affliction of the elderly,
presenting with progressive memory loss and dementia and terminating with death. There …

Sex differences are a well-known phenomenon in Alzheimer's disease (AD), with women
having a higher risk for AD than men. Many AD mouse models display a similar sex …