Neuropathological and behavioral features of an APP/PS1/MAPT (6xTg) transgenic model of Alzheimer's disease

SH Tag, B Kim, J Bae, KA Chang, HI Im - Molecular Brain, 2022 - Springer
Alzheimer's disease is associated with various brain dysfunctions, including memory
impairment, neuronal loss, astrocyte activation, amyloid-β plaques, and neurofibrillary …

Reduced social investigation and increased injurious behavior in transgenic 5xFAD mice

F Kosel, JS Hamilton, SL Harrison… - Journal of …, 2021 - Wiley Online Library
Social withdrawal and agitation/aggression are common behavioral and psychological
symptoms of dementia presented by Alzheimer's disease (AD) patients, with males …

Task-dependent learning and memory deficits in the TgF344-AD rat model of Alzheimer's disease: three key timepoints through middle-age in females

VE Bernaud, HL Bulen, VL Peña, SV Koebele… - Scientific reports, 2022 - nature.com
The TgF344 rat model of Alzheimer's disease (AD) provides a comprehensive
neuropathology presentation, with age-dependent development of tau tangles, amyloid-beta …

Behavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines

D Puzzo, L Lee, A Palmeri, G Calabrese… - Biochemical …, 2014 - Elsevier
In Alzheimer's disease (AD) basic research and drug discovery, mouse models are essential
resources for uncovering biological mechanisms, validating molecular targets and screening …

Differential effects of chronic stress on anxiety-like behavior and contextual fear conditioning in the TgF344-AD rat model of Alzheimer's disease

NS Pentkowski, SJ Bouquin, CR Maestas-Olguin… - Behavioural Brain …, 2022 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder that leads to
severe cognitive and functional impairments. Many AD patients also exhibit neuropsychiatric …

Identification of novel key molecules involved in spatial memory impairment in triple transgenic mice of Alzheimer's disease

M Ying, X Sui, Y Zhang, Q Sun, Z Qu, X Luo… - Molecular …, 2017 - Springer
The molecular mechanisms underlying cognitive impairment in Alzheimer's disease (AD)
remain largely unclear. In the present study, we were aimed to identify the potential key …

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

SJ Webster, AD Bachstetter, PT Nelson… - Frontiers in …, 2014 - frontiersin.org
The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …

Temporal Appearance of Enhanced Innate Anxiety in Alzheimer Model Mice

A Szabó, S Farkas, C Fazekas, P Correia, T Chaves… - Biomedicines, 2023 - mdpi.com
The prevalence of Alzheimer's disorder (AD) is increasing worldwide, and the co-morbid
anxiety is an important, albeit often neglected problem, which might appear early during …

[HTML][HTML] Age-related changes in species-typical behaviours in the 5xFAD mouse model of Alzheimer's disease from 4 to 16 months of age

TP O'Leary, RE Brown - Behavioural Brain Research, 2024 - Elsevier
Alzheimer's disease (AD) patients show age-related decreases in the ability to perform
activities of daily living and the decline in these activities is related to the severity of …

Protective effect of exercise training against the progression of Alzheimer's disease in 3xTg-AD mice

D Kim, J Cho, H Kang - Behavioural Brain Research, 2019 - Elsevier
Mechanisms underlying the protective effect of exercise training against the progression of
Alzheimer's disease (AD) are not fully understood. This study investigated the effects of …