Neuropathological and behavioral features of an APP/PS1/MAPT (6xTg) transgenic model of Alzheimer's disease
Alzheimer's disease is associated with various brain dysfunctions, including memory
impairment, neuronal loss, astrocyte activation, amyloid-β plaques, and neurofibrillary …
impairment, neuronal loss, astrocyte activation, amyloid-β plaques, and neurofibrillary …
Reduced social investigation and increased injurious behavior in transgenic 5xFAD mice
F Kosel, JS Hamilton, SL Harrison… - Journal of …, 2021 - Wiley Online Library
Social withdrawal and agitation/aggression are common behavioral and psychological
symptoms of dementia presented by Alzheimer's disease (AD) patients, with males …
symptoms of dementia presented by Alzheimer's disease (AD) patients, with males …
Task-dependent learning and memory deficits in the TgF344-AD rat model of Alzheimer's disease: three key timepoints through middle-age in females
VE Bernaud, HL Bulen, VL Peña, SV Koebele… - Scientific reports, 2022 - nature.com
The TgF344 rat model of Alzheimer's disease (AD) provides a comprehensive
neuropathology presentation, with age-dependent development of tau tangles, amyloid-beta …
neuropathology presentation, with age-dependent development of tau tangles, amyloid-beta …
Behavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines
D Puzzo, L Lee, A Palmeri, G Calabrese… - Biochemical …, 2014 - Elsevier
In Alzheimer's disease (AD) basic research and drug discovery, mouse models are essential
resources for uncovering biological mechanisms, validating molecular targets and screening …
resources for uncovering biological mechanisms, validating molecular targets and screening …
Differential effects of chronic stress on anxiety-like behavior and contextual fear conditioning in the TgF344-AD rat model of Alzheimer's disease
NS Pentkowski, SJ Bouquin, CR Maestas-Olguin… - Behavioural Brain …, 2022 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder that leads to
severe cognitive and functional impairments. Many AD patients also exhibit neuropsychiatric …
severe cognitive and functional impairments. Many AD patients also exhibit neuropsychiatric …
Identification of novel key molecules involved in spatial memory impairment in triple transgenic mice of Alzheimer's disease
M Ying, X Sui, Y Zhang, Q Sun, Z Qu, X Luo… - Molecular …, 2017 - Springer
The molecular mechanisms underlying cognitive impairment in Alzheimer's disease (AD)
remain largely unclear. In the present study, we were aimed to identify the potential key …
remain largely unclear. In the present study, we were aimed to identify the potential key …
Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models
The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …
Temporal Appearance of Enhanced Innate Anxiety in Alzheimer Model Mice
A Szabó, S Farkas, C Fazekas, P Correia, T Chaves… - Biomedicines, 2023 - mdpi.com
The prevalence of Alzheimer's disorder (AD) is increasing worldwide, and the co-morbid
anxiety is an important, albeit often neglected problem, which might appear early during …
anxiety is an important, albeit often neglected problem, which might appear early during …
[HTML][HTML] Age-related changes in species-typical behaviours in the 5xFAD mouse model of Alzheimer's disease from 4 to 16 months of age
TP O'Leary, RE Brown - Behavioural Brain Research, 2024 - Elsevier
Alzheimer's disease (AD) patients show age-related decreases in the ability to perform
activities of daily living and the decline in these activities is related to the severity of …
activities of daily living and the decline in these activities is related to the severity of …
Protective effect of exercise training against the progression of Alzheimer's disease in 3xTg-AD mice
Mechanisms underlying the protective effect of exercise training against the progression of
Alzheimer's disease (AD) are not fully understood. This study investigated the effects of …
Alzheimer's disease (AD) are not fully understood. This study investigated the effects of …