Mouse models of Alzheimer's disease (AD) are often tested for learning and memory deficits
using visuo-spatial tasks such as the Morris water maze. Performance on these tasks is …

Circadian disturbances, including a fragmented sleep–wake pattern and sundowning, are
commonly reported early in the progression of Alzheimer's disease (AD). These changes are …

The neuropathological correlates of Alzheimer's disease (AD) include amyloid-β (Aβ)
plaques and neurofibrillary tangles. To study the interaction between Aβ and tau and their …

Since 2000, a plethora of transgenic mouse models have been developed to reproduce the
main features of Alzheimer's disease (AD). Due to the complexity of the disease, no ideal …

Alzheimer's disease (AD), the most common neurodegenerative and dementing disorder, is
characterized by extracellular amyloid deposition, intracellular neurofibrillary tangle …

Mouse models of Alzheimer's disease (AD) show both cognitive and neuromotor
impairments. We measured motor ability and motor learning of male and female triple …

Despite the impact of pain in cognitive dysfunctions and affective disorders has been largely
studied, the research that examines pain dimensions in cognitive impairment or dementia is …

The severity of this pandemic's scenarios will leave significant psychological traces in low
resistant and resilient individuals. Increased incidence of depression, anxiety, obsessive …

Background: Preclinical Alzheimer's disease (AD) research strongly depends on transgenic
mouse models that display major symptoms of the disease. Although several AD mouse …

Behavioral assessment of genetically-manipulated mouse lines for Alzheimer's disease has
become an important index for determining the efficacy of therapeutic interventions and …