Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia
Abstract 16p11. 2 and 22q11. 2 Copy Number Variants (CNVs) confer high risk for Autism
Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder …
Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder …
Reciprocal copy number variations at 22q11. 2 produce distinct and convergent neurobehavioral impairments relevant for schizophrenia and autism spectrum …
A Lin, A Vajdi, L Kushan-Wells, G Helleman… - Biological …, 2020 - Elsevier
Abstract Background 22q11. 2 deletions and duplications are copy number variations
(CNVs) that predispose to developmental neuropsychiatric disorders. Both CNVs are …
(CNVs) that predispose to developmental neuropsychiatric disorders. Both CNVs are …
[HTML][HTML] The neurogenetics of functional connectivity alterations in autism: Insights from subtyping in 657 individuals
Background There is little consensus and controversial evidence on anatomical alterations
in the brains of people with autism spectrum disorder (ASD), due in part to the large …
in the brains of people with autism spectrum disorder (ASD), due in part to the large …
Genetic heterogeneity shapes brain connectivity in psychiatry
Background Polygenicity and genetic heterogeneity pose great challenges for studying
psychiatric conditions. Genetically informed approaches have been implemented in …
psychiatric conditions. Genetically informed approaches have been implemented in …
Dissociable disruptions in thalamic and hippocampal resting-state functional connectivity in youth with 22q11. 2 deletions
The 22q11. 2 deletion syndrome (22q11DS) is a recurrent copy number variant with high
penetrance for developmental neuropsychiatric disorders. Study of individuals with …
penetrance for developmental neuropsychiatric disorders. Study of individuals with …
Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes
Abstract Autism Spectrum Disorder (ASD) is characterized by substantial, yet highly
heterogeneous abnormalities in functional brain connectivity. However, the origin and …
heterogeneous abnormalities in functional brain connectivity. However, the origin and …
Diverse types of genetic variation converge on functional gene networks involved in schizophrenia
Despite the successful identification of several relevant genomic loci, the underlying
molecular mechanisms of schizophrenia remain largely unclear. We developed a …
molecular mechanisms of schizophrenia remain largely unclear. We developed a …
Autism-associated 16p11. 2 microdeletion impairs prefrontal functional connectivity in mouse and human
Human genetic studies are rapidly identifying variants that increase risk for
neurodevelopmental disorders. However, it remains unclear how specific mutations impact …
neurodevelopmental disorders. However, it remains unclear how specific mutations impact …
Dissecting autism and schizophrenia through neuroimaging genomics
Neuroimaging genomic studies of autism spectrum disorder and schizophrenia have mainly
adopted a 'top-down'approach, beginning with the behavioural diagnosis, and moving down …
adopted a 'top-down'approach, beginning with the behavioural diagnosis, and moving down …
[HTML][HTML] Connectome-wide mega-analysis reveals robust patterns of atypical functional connectivity in autism
Background Neuroimaging studies of functional connectivity (FC) in autism have been
hampered by small sample sizes and inconsistent findings with regard to whether …
hampered by small sample sizes and inconsistent findings with regard to whether …