Connecting genomic alterations to cancer biology with proteomics: the NCI Clinical Proteomic Tumor Analysis Consortium
The National Cancer Institute (NCI) Clinical Proteomic Tumor Analysis Consortium is
applying the latest generation of proteomic technologies to genomically annotated tumors …
applying the latest generation of proteomic technologies to genomically annotated tumors …
muTarget: a platform linking gene expression changes and mutation status in solid tumors
Large oncology repositories have paired genomic and transcriptomic data for all patients.
We used these data to perform two independent analyses: to identify gene expression …
We used these data to perform two independent analyses: to identify gene expression …
The status and impact of clinical tumor genome sequencing
KRM Shaw, A Maitra - Annual review of genomics and human …, 2019 - annualreviews.org
Since the discovery that DNA alterations initiate tumorigenesis, scientists and clinicians
have been exploring ways to counter these changes with targeted therapeutics. The …
have been exploring ways to counter these changes with targeted therapeutics. The …
Assessing the clinical utility of cancer genomic and proteomic data across tumor types
Molecular profiling of tumors promises to advance the clinical management of cancer, but
the benefits of integrating molecular data with traditional clinical variables have not been …
the benefits of integrating molecular data with traditional clinical variables have not been …
Translating genomics for precision cancer medicine
R Sameek, AM Chinnaiyan - Annual review of genomics and …, 2014 - annualreviews.org
The Human Genome Project not only provided the essential reference map for the human
genome but also stimulated the development of technology and analytic tools to process …
genome but also stimulated the development of technology and analytic tools to process …
Precision oncology: an overview
In this Special Series issue, Journal of Clinical Oncologypresents a systematic assessment
of cancer genomic information and its accelerating clinical impact. In the scientific literature …
of cancer genomic information and its accelerating clinical impact. In the scientific literature …
A computational tool to detect DNA alterations tailored to formalin-fixed paraffin-embedded samples in cancer clinical sequencing
M Kato, H Nakamura, M Nagai, T Kubo, A Elzawahry… - Genome medicine, 2018 - Springer
Advanced cancer genomics technologies are now being employed in clinical sequencing,
where next-generation sequencers are used to simultaneously identify multiple types of …
where next-generation sequencers are used to simultaneously identify multiple types of …
Detection of low prevalence somatic mutations in solid tumors with ultra-deep targeted sequencing
O Harismendy, RB Schwab, L Bao, J Olson… - Genome biology, 2011 - Springer
Ultra-deep targeted sequencing (UDT-Seq) can identify subclonal somatic mutations in
tumor samples. Early assays' limited breadth and depth restrict their clinical utility. Here, we …
tumor samples. Early assays' limited breadth and depth restrict their clinical utility. Here, we …
Precision medicine in oncology—toward the integrated targeting of somatic and germline genomic aberrations
TA Yap, A Johnson, F Meric-Bernstam - JAMA oncology, 2021 - jamanetwork.com
The successful practice of precision medicine requires the clinical integration of a trifecta of
(1) molecular testing of patients,(2) interpretation of molecular profiling results and …
(1) molecular testing of patients,(2) interpretation of molecular profiling results and …
Precision oncology: Charting a path forward to broader deployment of genomic profiling
Precision oncology: Charting a path forward to broader deployment of genomic profiling | PLOS
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