Mechanisms of B cell receptor activation and responses to B cell receptor inhibitors in B cell malignancies
The B cell receptor (BCR) pathway has been identified as a potential therapeutic target in a
number of common B cell malignancies, including chronic lymphocytic leukemia, diffuse …
number of common B cell malignancies, including chronic lymphocytic leukemia, diffuse …
Targeting the B cell receptor pathway in non-Hodgkin lymphoma
K Valla, CR Flowers, JL Koff - Expert opinion on investigational …, 2018 - Taylor & Francis
Introduction: Dysregulated B cell receptor (BCR) signaling has been identified as a potent
contributor to tumor survival in B cell non-Hodgkin lymphomas (NHLs). This pathway's …
contributor to tumor survival in B cell non-Hodgkin lymphomas (NHLs). This pathway's …
Regulation of B-cell receptor signaling and its therapeutic relevance in aggressive B-cell lymphomas
Simple Summary Dysregulated B-cell receptor (BCR) signaling is considered a potent
contributor to tumor survival in different subtypes of B-cell non-Hodgkin lymphomas (B …
contributor to tumor survival in different subtypes of B-cell non-Hodgkin lymphomas (B …
Targeting pathological B cell receptor signalling in lymphoid malignancies
Signalling through the B cell receptor (BCR) is central to the development and maintenance
of B cells. In light of the numerous proliferative and survival pathways activated downstream …
of B cells. In light of the numerous proliferative and survival pathways activated downstream …
B‐cell receptor signalling and its crosstalk with other pathways in normal and malignant cells
The physiology of B cells is intimately connected with the function of their B‐cell receptor
(BCR). B‐cell lymphomas frequently (dys) regulate BCR signalling and thus take advantage …
(BCR). B‐cell lymphomas frequently (dys) regulate BCR signalling and thus take advantage …
B-cell receptor signaling in the pathogenesis of lymphoid malignancies
K Bojarczuk, M Bobrowicz, M Dwojak, N Miazek… - Blood Cells, Molecules …, 2015 - Elsevier
B-cell receptor (BCR) signaling pathway plays a central role in B-lymphocyte development
and initiation of humoral immunity. Recently, BCR signaling pathway has been shown as a …
and initiation of humoral immunity. Recently, BCR signaling pathway has been shown as a …
Targeting the B-cell receptor signaling pathway in B lymphoid malignancies
M Buchner, M Müschen - Current opinion in hematology, 2014 - journals.lww.com
Targeting of the B-cell receptor tyrosine kinases spleen tyrosine kinase, Bruton's tyrosine
kinase, and phosphatidylinositol 3-kinase achieve promising clinical responses in various …
kinase, and phosphatidylinositol 3-kinase achieve promising clinical responses in various …
Targeting B-cell receptor signaling: changing the paradigm
N Fowler, E Davis - Hematology 2013, the American Society of …, 2013 - ashpublications.org
It is well known that signals emanating from the B-cell receptor (BCR) activate downstream
pathways to regulate the development and survival of normal B cells. In B-cell malignancies …
pathways to regulate the development and survival of normal B cells. In B-cell malignancies …
New insights into pre-BCR and BCR signalling with relevance to B cell malignancies
RC Rickert - Nature Reviews Immunology, 2013 - nature.com
The B cell receptor (BCR) and its precursor (pre-BCR) control B cell homeostasis,
differentiation and function. Moreover, aberrant pre-BCR and BCR signalling have a central …
differentiation and function. Moreover, aberrant pre-BCR and BCR signalling have a central …
Inhibitors of B-cell receptor signaling for patients with B-cell malignancies
The B-cell receptor (BCR) complex and its associated protein tyrosine kinases play a critical
role in the development, proliferation, and survival of normal or malignant B cells. Regulated …
role in the development, proliferation, and survival of normal or malignant B cells. Regulated …