The active form of vitamin D, 1, 25 (OH) 2 D 3, controls serum calcium levels by regulating
gene expressing in three calcium-handling tissues, the intestine, kidney, and bone. Mouse …

Calcium is required for the functioning of numerous biological processes and is essential for
skeletal health. The major source of new calcium is from the diet. The central role of vitamin …

The role of the vitamin D receptor (VDR) in maintaining skeletal health appears to be
complex and dependent on the physiological context. Global Vdr deletion in a mouse model …

High intestinal calcium (Ca) absorption efficiency is associated with high peak bone mass in
adolescents and reduced bone loss in adulthood. Transepithelial intestinal Ca absorption is …

Efficient intestinal calcium (Ca) and phosphate (Pi) absorption is necessary for optimal bone
mineralization during growth, the protection of bone in adults, and the prevention of …

There are several lines of evidence that demonstrate the ability of 1, 25-dihydroxyvitamin D
(1, 25 (OH) 2 D 3), acting via the vitamin D receptor (VDR) to mediate negative or positive …

Vitamin D contributes to the development and maintenance of bone. Evidence suggests
vitamin D status can also alter energy balance and gut health. In young animals, vitamin D …

Vitamin D, synthesized in the skin or absorbed from the diet, undergoes multi-step enzymatic
conversion to its active form, 1, 25-dihydroxy vitamin D [1, 25 (OH) 2 D], followed by …

Mouse genetic studies have demonstrated that the 1, 25-dihydroxyvitamin D [1, 25 (OH) 2 D]
endocrine system is required for calcium (Ca 2+) and bone homeostasis. These studies …

1, 25-Dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3) plays an integral role in calcium homeostasis
in higher organisms through its actions in the intestine, kidney, and skeleton. Interestingly …