20-Epi-1, 25-dihydroxyvitamin D3 (20-epi-1, 25 (OH) 2D3) is a vitamin D analog that exhibits
unique biologic properties. The mechanism (s) responsible for these activities remains …

Without the vitamin D receptor (VDR), adult mammals develop reduced intestinal calcium
absorption, rickets, and osteomalacia. Intestinal calcium absorption normally increases …

Vitamin D is a principal factor required for mineral and skeletal homeostasis. Vitamin D
deficiency during development causes rickets and in adults can result in osteomalacia and …

Even one century after its discovery, there are still many gaps in the understanding of the
vitamin D endocrine system. Inactivation of the vitamin D receptor (VDR) or the enzymes …

Recent studies in mice using genetic approaches have shed new light on the physiological
effects of 1, 25-dihydroxyvitamin D (1, 25 (OH) 2 D) and the vitamin D receptor (VDR) in …

Vitamin D was originally identified as a factor which cured rickets in children and
osteomalacia in adults. It was misnamed, since it is not an essential dietary constituent, but a …

Immobilization induces significant and progressive bone loss, with an increase in urinary
excretion and a decrease in intestinal absorption of calcium. These actions lead to negative …

Animal models show that vitamin D deficiency may have severe consequences for skeletal
health. However, most studies have been performed in young rodents for a relatively short …

Vitamin D and calcium are essential for bone formation, mineralization, and remodeling.
Recent studies demonstrated that an increased body mass can be detrimental to bone …

Efficient intestinal calcium (Ca) and phosphate (Pi) absorption is necessary for optimal bone
mineralization during growth, the protection of bone in adults, and the prevention of …