Insulin resistance (IR) refers to a reduction in the ability of insulin to exert its metabolic
effects in organs such as adipose tissue (AT) and skeletal muscle (SM), leading to chronic …

Obesity is a key player in the onset and progression of insulin resistance (IR), a state by
which insulin-sensitive cells fail to adequately respond to insulin action. IR is a reversible …

Insulin resistance (IR) has become a common health issue in medical practice. There are no
detailed data on IR prevalence, but it is an increasing problem due to its close association …

Insulin resistance is a metabolic disorder affecting multiple tissues and is a precursor event
to type 2 diabetes (T2D). As T2D affects over 425 million people globally, there is an …

Background Recent evidence indicates that insulin resistance (IR) in obesity may develop
independently in different organs, representing different etiologies toward type 2 diabetes …

Insulin resistance is the pivotal pathogenic component of many metabolic diseases,
including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of …

This review postulates and presents recent evidence that insulin resistance is initiated in the
adipose tissue and also suggests that the adipose tissue may play a pivotal role in the …

Abstract Background/Objectives Obesity-associated insulin resistance (IR) may develop in
multiple organs, representing different aetiologies towards cardiometabolic diseases. This …

In the transition from normal glucose tolerance (NGT) to type 2 diabetes mellitus (T2DM), the
role of β-cell dysfunction and peripheral insulin resistance (IR) is well established. However …

Currently, obesity has become a global health issue and is referred to as an epidemic.
Dysfunctional obese adipose tissue plays a pivotal role in the development of insulin …