High frequencies of Th1-type CD4+ T cells specific to HTLV-1 Env and Tax proteins in patients with HTLV-1–associated myelopathy/tropical spastic paraparesis

PKC Goon, E Hanon, T Igakura… - Blood, The Journal …, 2002 - ashpublications.org
CD4+ T cells are critical for inducing and maintaining efficient humoral and cellular immune
responses to pathogens. The CD4+ T-cell response in human T-lymphotropic virus 1 (HTLV …

Low frequency of CD94/NKG2A+ T lymphocytes in patients with HTLV-1–associated myelopathy/tropical spastic paraparesis, but not in asymptomatic carriers

M Saito, VM Braud, P Goon, E Hanon, GP Taylor… - blood, 2003 - ashpublications.org
Human natural killer (NK)–cell receptors are expressed by NK cells and some T cells,
primarily TCR+ CD8+ cytotoxic T lymphocytes (CTLs). Inhibitory NK cell receptors (iNKRs) …

Increased HTLV Type 1 Tax Specific CD8+ Cells in HTLV Type 1-Asociated Myelopathy/Tropical Spastic Paraparesis: Correlation with HTLV Type 1 Proviral Load

R Kubota, M Nagai, T Kawanishi, M Osame… - AIDS research and …, 2000 - liebertpub.com
Less than 1% of individuals infected with the human T lymphotropic virus type 1 (HTLV-1)
develop an inflammatory neurological disorder, termed HTLV-1-associated …

Increased Activated Human T Cell Lymphotropic Virus Type I (HTLV-I) Tax11-19-Specific Memory and Effector CD8+ Cells in Patients with HTLV-I-Associated …

M Nagai, R Kubota, TF Greten… - The Journal of …, 2001 - academic.oup.com
To discern the T cell subtype associated with T cell differentiation, the expression of
CD45RA and CD27 was measured from total CD8high cells and from human T cell …

Analysis of the T-cell receptor repertoire of human T-cell leukemia virus type 1 (HTLV-1) Tax-specific CD8+ cytotoxic T lymphocytes from patients with HTLV-1 …

U Utz, D Banks, S Jacobson, WE Biddison - Journal of virology, 1996 - Am Soc Microbiol
Human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic
paraparesis (HAM/TSP) is a chronic, progressive neurological disease characterized by …

IFN‐γ production in response to Tax 161–233, and frequency of CD4+ Foxp3+ and Lin HLA‐DRhigh CD123+ cells, discriminate HAM/TSP patients from …

I Best, G López, K Verdonck, E González… - …, 2009 - Wiley Online Library
Human T‐lymphotropic virus 1 (HTLV‐1) can cause HTLV‐1‐associated myelopathy/tropical
spastic paraparesis (HAM/TSP). The objective of this study was to gain insight into the …

Functional impairment of Tax-specific but not cytomegalovirus-specific CD8+ T lymphocytes in a minor population of asymptomatic human T-cell leukemia virus type 1 …

A Takamori, A Hasegawa, A Utsunomiya, Y Maeda… - Retrovirology, 2011 - Springer
Background Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia
(ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a small …

Degenerate specificity of HTLV-1–specific CD8+ T cells during viral replication in patients with HTLV-1–associated myelopathy (HAM/TSP)

R Kubota, Y Furukawa, S Izumo… - Blood, The Journal of …, 2003 - ashpublications.org
Human T-lymphotropic virus type 1 (HTLV-1)–associated myelopathy/tropical spastic
paraparesis (HAM/TSP) is an inflammatory neurologic disease caused by HTLV-1 infection …

Demonstration of human T lymphotropic virus type I (HTLV-I) tax-specific CD8+ lymphocytes directly in peripheral blood of HTLV-I-associated myelopathy/tropical …

R Kubota, T Kawanishi, H Matsubara… - The Journal of …, 1998 - journals.aai.org
Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic
paraparesis (HAM/TSP) is an inflammatory neurologic disease caused by HTLV-I infection …

Different cytokine production in tax-expressing cells between patients with human T cell lymphotropic virus type I (HTLV-I)–associated myelopathy/tropical spastic …

Y Furukawa, M Saito, W Matsumoto… - The Journal of …, 2003 - academic.oup.com
Human T cell lymphotropic virus type I (HTLV-I) provirus load has been reported to be
generally higher in patients with HTLV-I–associated myelopathy/tropical spastic paraparesis …