Dopaminergic neurons represent less than 1% of the total number of neurons in the brain.
This low amount of neurons regulates important brain functions such as motor control …

Degeneration of mesencephalic dopaminergic (mesDA) neurons is the pathological
hallmark of Parkinson's diseae. Study of the biological processes involved in physiological …

The ability to isolate ventral midbrain (VM) precursor cells and neurons provides a powerful
means to characterize their differentiation properties and to study their potential for restoring …

In Parkinson's disease (PD) midbrain dopaminergic (DA) neurons degenerate and die,
causing loss of motor function. Currently no therapies exist to ameliorate neurodegeneration …

Human-derived neuronal cell lines are progressively being utilized in understanding
neurobiology and preclinical translational research as they are biologically more relevant …

Midbrain dopamine (DA) neurons play an essential role in modulating motor control, and
their degeneration is the hallmark feature of Parkinson's disease (PD). In vitro production of …

Functional and reliable in vitro models of Parkinson's disease (PD) are valuable for studying
mechanisms of dopaminergic degeneration before proceeding to animal testing. At present …

Generation of precisely patterned neural cells from human pluripotent stem cells (hPSCs) is
instrumental in developing disease models and stem cell therapies. Here, we provide a …

Parkinson's disease (PD) affects at least 6.5 million people worldwide, irrespective of
gender, social, ethnic, economic, or geographic boundaries. Key symptoms, such as tremor …

Parkinson's disease (PD) is the second most common neurodegenerative disorder and has
both unknown etiology and non-curative therapeutic options. Patients begin to present the …