Primary culture of mouse dopaminergic neurons
F Gaven, P Marin, S Claeysen - JoVE (Journal of Visualized Experiments), 2014 - jove.com
Dopaminergic neurons represent less than 1% of the total number of neurons in the brain.
This low amount of neurons regulates important brain functions such as motor control …
This low amount of neurons regulates important brain functions such as motor control …
Isolation, culture and long-term maintenance of primary mesencephalic dopaminergic neurons from embryonic rodent brains
M Weinert, T Selvakumar, TS Tierney… - JoVE (Journal of …, 2015 - jove.com
Degeneration of mesencephalic dopaminergic (mesDA) neurons is the pathological
hallmark of Parkinson's diseae. Study of the biological processes involved in physiological …
hallmark of Parkinson's diseae. Study of the biological processes involved in physiological …
Isolation and culture of ventral mesencephalic precursor cells and dopaminergic neurons from rodent brains
J Pruszak, L Just, O Isacson… - Current protocols in stem …, 2009 - Wiley Online Library
The ability to isolate ventral midbrain (VM) precursor cells and neurons provides a powerful
means to characterize their differentiation properties and to study their potential for restoring …
means to characterize their differentiation properties and to study their potential for restoring …
Medium-throughput computer aided micro-island method to assay embryonic dopaminergic neuron cultures in vitro
A Planken, LL Porokuokka, AL Hänninen… - Journal of neuroscience …, 2010 - Elsevier
In Parkinson's disease (PD) midbrain dopaminergic (DA) neurons degenerate and die,
causing loss of motor function. Currently no therapies exist to ameliorate neurodegeneration …
causing loss of motor function. Currently no therapies exist to ameliorate neurodegeneration …
[HTML][HTML] Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson's disease
Human-derived neuronal cell lines are progressively being utilized in understanding
neurobiology and preclinical translational research as they are biologically more relevant …
neurobiology and preclinical translational research as they are biologically more relevant …
Making and repairing the mammalian brain—in vitro production of dopaminergic neurons
AL Perrier, L Studer - Seminars in cell & developmental biology, 2003 - Elsevier
Midbrain dopamine (DA) neurons play an essential role in modulating motor control, and
their degeneration is the hallmark feature of Parkinson's disease (PD). In vitro production of …
their degeneration is the hallmark feature of Parkinson's disease (PD). In vitro production of …
An organotypic culture model to study nigro-striatal degeneration
F Cavaliere, E San Vicente, C Matute - Journal of neuroscience methods, 2010 - Elsevier
Functional and reliable in vitro models of Parkinson's disease (PD) are valuable for studying
mechanisms of dopaminergic degeneration before proceeding to animal testing. At present …
mechanisms of dopaminergic degeneration before proceeding to animal testing. At present …
Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation
Generation of precisely patterned neural cells from human pluripotent stem cells (hPSCs) is
instrumental in developing disease models and stem cell therapies. Here, we provide a …
instrumental in developing disease models and stem cell therapies. Here, we provide a …
Murine model for Parkinson's disease: from 6-OH dopamine lesion to behavioral test
FSL da Conceição, S Ngo-Abdalla, JC Houzel… - JoVE (Journal of …, 2010 - jove.com
Parkinson's disease (PD) affects at least 6.5 million people worldwide, irrespective of
gender, social, ethnic, economic, or geographic boundaries. Key symptoms, such as tremor …
gender, social, ethnic, economic, or geographic boundaries. Key symptoms, such as tremor …
Mimicking Parkinson's disease in a dish: merits and pitfalls of the most commonly used dopaminergic in vitro models
FM Lopes, IJ Bristot, LL Da Motta, RB Parsons… - NeuroMolecular …, 2017 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disorder and has
both unknown etiology and non-curative therapeutic options. Patients begin to present the …
both unknown etiology and non-curative therapeutic options. Patients begin to present the …