The five genes of the lysyl oxidase family encode enzymes that covalently cross-link
components of the extracellular matrix, such as various types of collagen and elastin, and …

Lysyl oxidase (LOX) and its four congeners, lysyl oxidase-like 1 (LOXL1),-2,-3, and-4, have
received much investigative attention in recent years. LOX itself, is the prototypic form of …

In this mini-review, we discuss the physiological and pathological roles of lysyl oxidase
(LOX) and its family, LOX-like proteins (LOXL), in relation to prognosis of major cancers. The …

Introduction: The lysyl oxidase family of enzymes is classically known as being required for
connective tissue maturation by oxidizing lysine residues in elastin and lysine and …

Lysyl oxidase (LOX) oxidizes the side chain of peptidyl lysine converting specific lysine
residues to residues of α-aminoadipic-δ-semialdehyde. This posttranslational chemical …

Lysyl oxidase is an extracellular matrix, copper–dependent amine oxidase that catalyzes a
key enzymatic step in the crosslinking of collagen and elastin. The enzyme is synthesized as …

The lysyl oxidase family comprises five members in mammals, lysyl oxidase (LOX) and four
lysyl oxidase like proteins (LOXL1-4). They are copper amine oxidases with a highly …

The mechanical properties of extracellular matrix (ECM) and connective tissues is largely
dependent on the collagen and elastin structure. Lysyl oxidase (LOX) plays a critical role in …

The lysyl oxidases (LOXs) are a family of enzymes deputed to cross-link collagen and
elastin, shaping the structure and strength of the extracellular matrix (ECM). However, many …

Abstract Lysyl oxidases (LysOX; EC 1.4. 3.13, protein-lysine 6-oxidases) are extracellular
copper enzymes that catalyze the cross-linking of collagens or elastin in the extracellular …