A new exciting area in cancer research is the study of cancer stem cells (CSCs) and the
translational implications for putative epigenetic therapies targeted against them …

LSD1 was the first histone demethylase identified by Professor Shi Yang and his team
members in 2004. LSD1 employs FAD as its cofactor, which catalyzes the demethylation of …

Epigenetic mechanisms underlie the phenotypic plasticity of cells, while aberrant epigenetic
regulation through genetic mutations and/or misregulated expression of epigenetic factors …

Histone methylation plays a key role in the regulation of chromatin structure, and its
dynamics regulates important cellular processes. The investigation of the role of alterations …

Breast cancer is the leading cause of cancer death in the female population, despite
advances in diagnosis and treatment. The highly heterogeneous nature of the disease …

Abstract Lysine (K)-specific demethylase 1A (LSD1/KDM1A) has been identified as a
potential therapeutic target in solid cancers and more recently in acute myeloid leukemia …

Abstract Lysine-specific demethylase 1 (LSD1) targets mono-or di-methylated histone H3K4
and H3K9 as well as non-histone substrates and functions in the regulation of gene …

Lysine specific demethylase 1 (LSD1) is a key epigenetic eraser enzyme implicated in
cancer metastases and recurrence. Nuclear LSD1 phosphorylated at serine 111 (nLSD1p) …

Among all cancers, colorectal cancer (CRC) is the 3rd most common and the 2nd leading
cause of death worldwide. New therapeutic strategies are required to target cancer stem …

Self-renewing somatic tissues depend upon the proper balance of chromatin-modifying
enzymes to coordinate progenitor cell maintenance and differentiation, disruption of which …