[HTML][HTML] On temporal scale-free non-periodic stimulation and its mechanisms as an infinite improbability drive of the brain's functional connectogram

VR Cota, SAV Cançado, MFD Moraes - Frontiers in Neuroinformatics, 2023 - frontiersin.org
Rationalized development of electrical stimulation (ES) therapy is of paramount importance.
Not only it will foster new techniques and technologies with increased levels of safety …

Implementation of Intra and Extracellular Nonperiodic Scale-Free Stimulation in silico for the NEURON Simulator

HCB Terra, FS Borges, MFD Moraes… - Latin American Workshop …, 2021 - Springer
Electrical stimulation of the brain is a largely used alternative for the treatment of myriad
neurological disorders. Although recognizably efficacious and safe, many details of the …

[HTML][HTML] Nonperiodic stimulation for the treatment of refractory epilepsy: Applications, mechanisms, and novel insights

VR Cota, JC de Oliveira, LCM Damázio… - Epilepsy & Behavior, 2021 - Elsevier
Electrical stimulation of the central nervous system is a promising alternative for the
treatment of pharmacoresistant epilepsy. Successful clinical and experimental stimulation is …

[HTML][HTML] The next move in neuromodulation therapy: a question of timing

J Modolo, A Legros, A Beuter - Frontiers in Computational …, 2015 - frontiersin.org
The effect of time-varying electrical currents (AC) on neuronal activity is currently the focus of
intense translational and multidisciplinary research efforts. Thanks to a broad range of …

[HTML][HTML] Temporally targeted interactions with pathologic oscillations as therapeutical targets in epilepsy and beyond

T Földi, ML Lőrincz, A Berényi - Frontiers in Neural Circuits, 2021 - frontiersin.org
Self-organized neuronal oscillations rely on precisely orchestrated ensemble activity in
reverberating neuronal networks. Chronic, non-malignant disorders of the brain are often …

The epileptic amygdala: toward the development of a neural prosthesis by temporally coded electrical stimulation

VR Cota, BMB Drabowski… - Journal of …, 2016 - Wiley Online Library
Many patients with epilepsy do not obtain proper control of their seizures through
conventional treatment. We review aspects of the pathophysiology underlying epileptic …

[HTML][HTML] Delayed closed-loop neurostimulation for the treatment of pathological brain rhythms in mental disorders: a computational study

T Wahl, J Riedinger, M Duprez, A Hutt - Frontiers in Neuroscience, 2023 - frontiersin.org
Mental disorders are among the top most demanding challenges in world-wide health. A
large number of mental disorders exhibit pathological rhythms, which serve as the disorders …

[HTML][HTML] Transcranial electric stimulation for precision medicine: a spatiomechanistic framework

F Yavari, MA Nitsche, H Ekhtiari - Frontiers in human neuroscience, 2017 - frontiersin.org
During recent years, non-invasive brain stimulation, including transcranial electrical
stimulation (tES) in general, and transcranial direct current stimulation (tDCS) in particular …

[HTML][HTML] Case report: Embedding “digital chronotherapy” into medical devices—a canine validation for controlling status epilepticus through multi-scale rhythmic brain …

M Zamora, S Meller, F Kajin, JJ Sermon… - Frontiers in …, 2021 - frontiersin.org
Circadian and other physiological rhythms play a key role in both normal homeostasis and
disease processes. Such is the case of circadian and infradian seizure patterns observed in …

[HTML][HTML] A connectome-based, corticothalamic model of state-and stimulation-dependent modulation of rhythmic neural activity and connectivity

JD Griffiths, AR McIntosh, J Lefebvre - Frontiers in computational …, 2020 - frontiersin.org
Rhythmic activity in the brain fluctuates with behaviour and cognitive state, through a
combination of coexisting and interacting frequencies. At large spatial scales such as those …