Neurobiology of dysregulated motivational systems in drug addiction
The progression from recreational drug use to drug addiction impacts multiple
neurobiological processes and can be conceptualized as a transition from positive to …
neurobiological processes and can be conceptualized as a transition from positive to …
How preclinical models evolved to resemble the diagnostic criteria of drug addiction
Drug addiction is a complex neuropsychiatric disorder that affects a subset of the individuals
who take drugs. It is characterized by maladaptive drug-seeking habits that are maintained …
who take drugs. It is characterized by maladaptive drug-seeking habits that are maintained …
The neurocircuitry of addiction: Implications for treatment
GF Koob - Clinical Neuroscience Research, 2005 - Elsevier
Drug addiction is a chronic, relapsing disorder characterized by a compulsion to seek and
take drugs, loss of control in limiting intake, and emergence of a negative emotional state in …
take drugs, loss of control in limiting intake, and emergence of a negative emotional state in …
Experimental medicine in drug addiction: towards behavioral, cognitive and neurobiological biomarkers
T Duka, HS Crombag… - Journal of …, 2011 - journals.sagepub.com
Several theoretical frameworks have been developed to understand putative processes and
mechanisms involved in addiction. Whilst these 'theories of addiction'disagree about …
mechanisms involved in addiction. Whilst these 'theories of addiction'disagree about …
Neurocognitive and neuroimaging evidence of behavioural dysregulation in human drug addiction: implications for diagnosis, treatment and prevention
Neuropsychological and neuroimaging studies have generated a wealth of data
demonstrating structural and functional brain changes, as well as cognitive deficits in drug …
demonstrating structural and functional brain changes, as well as cognitive deficits in drug …
The tonic/phasic model of dopamine system regulation: its relevance for understanding how stimulant abuse can alter basal ganglia function
AA Grace - Drug and alcohol dependence, 1995 - Elsevier
The changes in dopamine system regulation occurring during stimulant administration are
examined in relation to a new model of dopamine system function. This model is based on …
examined in relation to a new model of dopamine system function. This model is based on …
Neurobiology of addiction
GF Koob - Addiction Counseling Review. New York2004, 2015 - books.google.com
Drug addiction is a chronically relapsing disorder characterized by 1) compulsion to seek
and take the drug, 2) loss of control in limiting intake, and 3) emergence of a negative …
and take the drug, 2) loss of control in limiting intake, and 3) emergence of a negative …
The persistence of addiction is better explained by socioeconomic deprivation-related factors powerfully motivating goal-directed drug choice than by automaticity …
L Hogarth - Evaluating the brain disease model of addiction, 2022 - taylorfrancis.com
Since its inception, the brain disease model of addiction (BDMA) has iteratively explained
the puzzle of addiction (why drug use persists despite harms) by appealing to various …
the puzzle of addiction (why drug use persists despite harms) by appealing to various …
Drug addiction: functional neurotoxicity of the brain reward systems
Drug addiction is a chronic relapsing brain disorder characterized by a compulsion to take a
drug with loss of control over drug intake. The hypothesis under discussion here is that …
drug with loss of control over drug intake. The hypothesis under discussion here is that …