[HTML][HTML] HPV transcript expression affects cervical cancer response to chemoradiation

FJ Ruiz, M Inkman, R Rashmi, N Muhammad… - JCI insight, 2021 - ncbi.nlm.nih.gov
Persistent HPV infection is causative for the majority of cervical cancer cases; however,
current guidelines do not require HPV testing for newly diagnosed cervical cancer. Using an …

Genomic characterization of cervical cancer based on human papillomavirus status

L Zhang, Y Jiang, X Lu, H Zhao, C Chen, Y Wang… - Gynecologic …, 2019 - Elsevier
Objective It is uncommon for cervical cancer patients to be diagnosed without a human
papillomavirus (HPV) infection. As prophylactic vaccines against high-risk HPV types are an …

Decreased local immune response and retained HPV gene expression during chemoradiotherapy are associated with treatment resistance and death from cervical …

PF Cosper, C McNair, I González… - … journal of cancer, 2020 - Wiley Online Library
More than one‐third of patients with locally advanced cervical cancer do not respond to
chemoradiation therapy (CRT). We aimed to characterize the transcriptional landscape of …

Genetic variations in human papillomavirus and cervical cancer outcomes

JS Rader, SW Tsaih, D Fullin… - … journal of cancer, 2019 - Wiley Online Library
Cervical cancer is driven by persistent infection of human papillomavirus (HPV), which is
influenced by HPV type and intratypic variants, yet the impact of HPV type and intratypic …

[HTML][HTML] Findings of multiple HPV genotypes in cervical carcinoma are associated with poor cancer-specific survival in a Swedish cohort of cervical cancer primarily …

M Kaliff, B Sorbe, LB Mordhorst, G Helenius… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Cervical cancer (CC) is one of the most common cancers in women and virtually all cases of
CC are a result of a persistent infection of human papillomavirus (HPV). For disease …

[HTML][HTML] Identification and characterization of HPV-independent cervical cancers

CE Banister, C Liu, L Pirisi, KE Creek, PJ Buckhaults - Oncotarget, 2017 - ncbi.nlm.nih.gov
Background Human papillomavirus (HPV) initiates cervical cancer, and continuous
expression of HPV oncogenes E6 and E7 is thought to be necessary to maintain malignant …

[HTML][HTML] Variations in HPV function are associated with survival in squamous cell carcinoma

FO Gleber-Netto, X Rao, T Guo, Y Xi, M Gao, L Shen… - JCI insight, 2019 - ncbi.nlm.nih.gov
Incidence of HPV+ oropharyngeal squamous cell carcinoma (OPSCC) has been increasing
dramatically. Although long-term survival rates for these patients are high, they often suffer …

The transcriptional regulator gene E2 of the Human Papillomavirus (HPV) 16 influences the radiosensitivity of cervical keratinocytes

K Lindel, S Rieken, S Daffinger, KJ Weber… - Radiation …, 2012 - Springer
Background Clinical studies have demonstrated that HPV induced tumors constitute a
specific subclass of cancer with a better response to radiation treatment. The purpose of this …

The HPV16 E6 and E7 proteins and the radiation resistance of cervical carcinoma

L Hampson, ESAE Hady, JV Moore… - The FASEB …, 2001 - Wiley Online Library
Using a murine transplantation model, we have investigated the function of the HPV16 E6
and E7 proteins in the development of radiation resistance in advanced cervical carcinoma …

A novel gene signature associated with poor response to chemoradiotherapy in patients with locally advanced cervical cancer

KH Kim, JS Chang, YB Kim - International Journal of Radiation Oncology …, 2021 - Elsevier
Purpose/Objective (s) We aimed to investigate the distinct transcriptional landscape in the
poor responders to concurrent chemoradiotherapy (CCRT) and to gain mechanistic insights …