Measuring creatinine clearance is the most accurate way for calculating the proper continuous infusion meropenem dose for empirical treatment of severe gram …
C Troisi, PG Cojutti, M Rinaldi, C Laici, A Siniscalchi… - Pharmaceutics, 2023 - mdpi.com
Assessment of glomerular filtration rate (GFR) is necessary for dose adjustments of beta-
lactam that are excreted by the kidneys, such as meropenem. The aim of this study was to …
lactam that are excreted by the kidneys, such as meropenem. The aim of this study was to …
Development of a dosing nomogram for continuous-infusion meropenem in critically ill patients based on a validated population pharmacokinetic model
IK Minichmayr, JA Roberts, OR Frey… - Journal of …, 2018 - academic.oup.com
Background Optimal antibiotic exposure is a vital but challenging prerequisite for achieving
clinical success in ICU patients. Objectives To develop and externally validate a population …
clinical success in ICU patients. Objectives To develop and externally validate a population …
A nonparametric pharmacokinetic approach to determine the optimal dosing regimen for 30-minute and 3-hour meropenem infusions in critically ill patients
Background: Pharmacokinetics of meropenem differ widely in the critically ill population. It is
imperative to maintain meropenem concentrations above the inhibitory concentrations for …
imperative to maintain meropenem concentrations above the inhibitory concentrations for …
Dosing nomograms for attaining optimum concentrations of meropenem by continuous infusion in critically ill patients with severe gram-negative infections: a …
F Pea, P Viale, P Cojutti, M Furlanut - Antimicrobial agents and …, 2012 - Am Soc Microbiol
The worrisome increase in Gram-negative bacteria with borderline susceptibility to
carbapenems and of carbapenemase-producing Enterobacteriaceae has significantly …
carbapenems and of carbapenemase-producing Enterobacteriaceae has significantly …
Population Pharmacokinetic Model and Dosing Simulation of Meropenem Using Measured Creatinine Clearance for Patients with Sepsis
S Fukumoto, M Ohbayashi, A Okada… - Therapeutic Drug …, 2023 - journals.lww.com
Purpose: Creatinine clearance (CCr) and pharmacokinetic parameters are markedly
affected by pathophysiological changes in patients with sepsis. However, only a few reports …
affected by pathophysiological changes in patients with sepsis. However, only a few reports …
Meropenem target attainment and population pharmacokinetics in critically ill septic patients with preserved or increased renal function
M Gijsen, O Elkayal, P Annaert… - Infection and Drug …, 2022 - Taylor & Francis
Purpose Critically ill patients with preserved or increased renal function have been shown to
be at risk of underexposure to meropenem. Although many meropenem population …
be at risk of underexposure to meropenem. Although many meropenem population …
Development of a dosing algorithm for meropenem in critically ill patients based on a population pharmacokinetic/pharmacodynamic analysis
L Ehmann, M Zoller, IK Minichmayr, C Scharf… - International journal of …, 2019 - Elsevier
Effective antibiotic dosing is vital for therapeutic success in critically ill patients. This work
aimed to develop an algorithm to identify appropriate meropenem dosing in critically ill …
aimed to develop an algorithm to identify appropriate meropenem dosing in critically ill …
Population pharmacokinetic meta-analysis and dosing recommendation for meropenem in critically ill patients receiving continuous renal replacement therapy
Y Peng, Z Cheng, F Xie - Antimicrobial Agents and Chemotherapy, 2022 - Am Soc Microbiol
The optimal dosing regimen for meropenem in critically ill patients undergoing continuous
renal replacement therapy (CRRT) remains undefined due to small studied sample sizes …
renal replacement therapy (CRRT) remains undefined due to small studied sample sizes …
Optimization of meropenem dosage in the critically ill population based on renal function
JL Crandon, RE Ariano, SA Zelenitsky, AM Nicasio… - Intensive care …, 2011 - Springer
Purpose To develop a meropenem population pharmacokinetic model in critically ill patients
with particular focus on optimizing dosing regimens based on renal function. Methods …
with particular focus on optimizing dosing regimens based on renal function. Methods …
Effect of renal clearance and continuous renal replacement therapy on appropriateness of recommended meropenem dosing regimens in critically ill patients with …
R Burger, M Guidi, V Calpini, F Lamoth… - Journal of …, 2018 - academic.oup.com
Background Meropenem plasma concentration above a pathogen's MIC over the whole
dosing interval (100% ƒ T> MIC) is a determinant of outcome in severe infections. Significant …
dosing interval (100% ƒ T> MIC) is a determinant of outcome in severe infections. Significant …