Neuroblastoma is an extracranial solid tumor which develops in early childhood and still has
a poor prognosis. One strategy to increase cure rates is the identification of patient-specific …

Neuroblastoma (NB) is the most common extracranial tumor in children resulting in
substantial morbidity and mortality. A deeper understanding of the NB tumor …

There is an urgent for a novel approach to cancer research with 1.7 million new cases of
cancer occurring every year in the United States of America. Tumor models offer promise as …

An in vitro screening system for anti-cancer drugs cannot exactly reflect the efficacy of drugs
in vivo, without mimicking the tumour microenvironment (TME), which comprises cancer …

Glioblastoma multiforme (GBM), a deadly primary brain cancer, exhibits invasive
proliferation into healthy brain tissue. Currently, novel treatment methods are being …

Chemotherapy is one of the most effective cancer treatments. Starting from the discovery of
new molecular entities, it usually takes about 10 years and 2 billion US dollars to bring an …

The development of a scalable and highly reproducible in vitro tumor microenvironment
(TME) platform still sheds light on new insights into cancer metastasis mechanisms and …

Recent advances in microfluidic organ-on-a-chip technology have enabled the growth of 3D
microphysiological systems for diverse biological studies. Fabrication and usage limitations …

The integration of tumor-on-a-chip technology with mini-tissues or organoids has emerged
as a powerful approach in cancer research and drug development. This review provides an …

The ideal in vitro recreation of the micro-tumor niche—although much needed for a better
understanding of cancer etiology and development of better anticancer therapies—is highly …