Esophageal squamous cell cancer (ESCC) is a common malignancy with a poor 5-year
overall survival in China. Altered DNA damage repair (DDR) pathways are associated with a …

Background Defects in DNA damage repair (DDR) pathways lead to genomic instability and
oncogenesis. DDR deficiency is prevalent in esophageal squamous cell carcinoma (ESCC) …

Esophageal cancer is a global distributed malignant cancer. China is one of countries with
high incidence of esophageal cancer [1]. Radiotherapy has been confirmed as one of the …

Background DNA damage repair (DDR) is a critical process that maintains genomic integrity
and plays essential roles at both the cellular and organismic levels. Here, we aimed to …

Background Esophageal squamous cell carcinoma (ESCC) is one of the most lethal cancer
due to insufficient actionable molecules. Radiotherapy (RT) plays a vital role in the treatment …

Background Radiotherapy has recently become more common for the treatment of
esophageal squamous cell carcinoma (ESCC). Radioresistance, on the other hand …

Background Radiotherapy plays an important effect on the standard therapy of esophageal
squamous cell carcinoma (ESCC). However, the efficacy of the therapy is limited and a few …

Background Recent data in esophageal cancer suggests the variant allele of a single-
nucleotide polymorphism (SNP) in XRCC1 may be associated with resistance to …

Esophageal squamous cell carcinoma (ESCC) often recurs after chemoradiotherapy, and
the prognosis of ESCC after chemoradiotherapy has not improved over the past few …

Esophageal squamous cell carcinoma (ESCC) is the sixth most common cause of cancer-
related mortality worldwide, with more than half of them occurred in China. Radiotherapy …