Background: Cognitive reserve allows for active compensation during neuropathology.
Here, we examine electrophysiological evidence for active compensation in Alzheimer's …

Alzheimer's disease (AD) is associated with amyloidosis and dysfunction of the cholinergic
system, which is crucial for learning and memory. However, the nature of acetylcholine …

Degeneration in neuronal nuclei producing the neuromodulators acetylcholine and
norepinephrine is a hallmark of Alzheimer's disease (AD). Therapeutic interventions that …

Acetylcholine in the neocortex is critical for executive function. Degeneration of the basal
forebrain cholinergic system is associated with cognitive decline in aging and Alzheimer's …

Attention deficits in Alzheimer's disease can exacerbate its other cognitive symptoms, yet
relevant disruptions of key prefrontal circuitry are not well understood. Here, in the …

The basal forebrain cholinergic system (BFCS) has long been implicated in age-related
cognitive changes and the pathophysiology of Alzheimer's disease (AD). Limitations of …

Alzheimer's disease (AD) is the most common form of dementia worldwide. It is mostly
known for its devastating effect on memory and learning but behavioral alterations …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
accumulation of toxic misfolded proteins, which are believed to have propagated from …

Disruption of attention is an early and disabling symptom of Alzheimer's disease (AD). The
underlying cellular mechanisms are poorly understood and treatment options for patients …

It is increasingly clear that the public health burden of Alzheimer's disease (AD) is not solely
due to cognitive decline but also to neuropsychiatric symptoms (NPS). NPS such as …