Cellular perturbations underlying Alzheimer's disease are primarily studied in human
postmortem samples and model organisms. Here we generated a single-nucleus atlas from …

Alzheimer's disease, the most common neurodegenerative disorder of senile dementia, is
characterized by two major morpho-pathological hallmarks. Deposition of extracellular …

In the past years, major efforts have been made to understand the genetics and molecular
pathogenesis of Alzheimer's disease (AD), which has been translated into extensive …

Autopsy work reported that neuronal density in the locus coeruleus (LC) provides neural
reserve against cognitive decline in dementia. Recent neuroimaging and pharmacological …

Summary Alzheimer's disease (AD), the leading cause of dementia, affects millions of
people worldwide. With no disease-modifying medication currently available, the human toll …

Background The brain regions that show early increase of beta‐amyloid (Aβ) in Alzheimer's
disease (AD) overlap with the default mode network (DMN)(Palmqvist, S. et. al., 2017) …

There are few studies on the clinical and neurochemical correlates of postsynaptic
cholinergic dysfunction in Alzheimer's disease (AD). We have previously found that …

Sir, We agree with the suggestions of Gauthier and colleagues (Gauthier et al., 2018) for a
more structured approach to therapy in Alzheimer's disease. We also agree that there is …

Acetylcholine promotes cognitive function through the regulation of cortical circuits. In this
issue of Neuron, Urban-Ciecko et al.(2018) demonstrate how this neuromodulator can …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder of cognitive function
whose cellular pathology and molecular etiology have been increasingly and dramatically …