The prefrontal cortex integrates a variety of cognition-related inputs, either unidirectional, eg,
from the hippocampal formation, or bidirectional, eg, with the limbic thalamus. While the …

Sir, We agree with the suggestions of Gauthier and colleagues (Gauthier et al., 2018) for a
more structured approach to therapy in Alzheimer's disease. We also agree that there is …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by memory and
cognitive loss, and represents the leading cause of dementia in elderly people. Besides the …

Alzheimer's disease (AD) is the most common cause of dementia in the elderly. At the early
stages of AD development, the soluble β-amyloid (Aβ) induces synaptic dysfunction …

Objectives: The present study investigated the independent and synergistic effects of
amyloid beta (Aβ1-42) and phosphorylated tau (Ptau) pathologies on neuropsychological …

There are few studies on the clinical and neurochemical correlates of postsynaptic
cholinergic dysfunction in Alzheimer's disease (AD). We have previously found that …

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder linked to cognitive
decline. To understand how specific neuronal circuits are impaired in AD, we have used …

Abstract See Grinberg and Heinsen (doi: 10.1093/brain/awx261) for a scientific commentary
on this article. Clinical evidence suggests that aberrant tau accumulation in the locus …

Background Autopsy work reported that neuronal density in the locus coeruleus (LC)
provides neural reserve against cognitive decline in dementia. Recent neuroimaging and …

The early stages of Alzheimer's disease (AD) have been linked to microcircuit dysfunction
and pathophysiological neuronal firing in several brain regions. Inhibitory GABAergic …