The prefrontal cortex integrates a variety of cognition-related inputs, either unidirectional, eg,
from the hippocampal formation, or bidirectional, eg, with the limbic thalamus. While the …

Functional network activity alterations are one of the earliest hallmarks of Alzheimer's
disease (AD), detected prior to amyloidosis and tauopathy. Better understanding the …

The disease's trajectory of Alzheimer's disease (AD) is associated with and worsened by
hippocampal hyperexcitability. Here we show that during the asymptomatic stage in a knock …

Acetylcholine (ACh) has a crucial role in the peripheral and central nervous systems. The
enzyme choline acetyltransferase (ChAT) is responsible for synthesizing ACh from acetyl …

Humans often commit errors when they are distracted by irrelevant information and no
longer focus on what is relevant to the task at hand. Adjustments following errors are …

The basal forebrain cholinergic complex comprising medial septum, horizontal and vertical
diagonal band of Broca, and nucleus basalis of Meynert provides the mayor cholinergic …

Dysregulated homeostasis of neural activity has been hypothesized to drive Alzheimer's
disease (AD) pathogenesis. AD begins with a decades-long presymptomatic phase, but …

The functional relevance of septo-hippocampal cholinergic (SHC) degeneration to the
degradation of hippocampus-dependent declarative memory (DM) in aging and Alzheimer's …

Alzheimer's disease (AD), marked by cognitive impairment, predominantly affects the brain
regions regulated by cholinergic innervation, such as the cerebral cortex and hippocampus …

Activation of cortical nicotinic receptors by cholinergic axons from the basal forebrain (BF)
significantly impacts cortical function, and the loss of nicotinic receptors is a hallmark of …